Effect of relaxation therapy on patients with primary liver cancer complicated with portal hypertension after jugular intrahepatic portal shunt
Objective To analyze the effects of relaxation therapy on pain stress response and adverse mood in patients with primary liver cancer complicated with portal hypertension after jugular intrahepatic portal shunt(TIPS).Methods A total of 92 patients with primary liver cancer complicated with portal hypertension after TIPS at First Hospital,Henan University of Science and Technology from June 2020 to June 2022 were selected for the randomized controlled trial,and were divided into a control group and an experimental group by the random number table method,with 46 cases in each group.In the control group,there were 25 males and 21 females;there were 8 cases of stage A,20 cases of stage B,and 18 of stage C;they were 40-76(55.16±5.80)years old.In the experimental group,there were 27 males and 19 females;there were 10 cases of stage A,21 cases of stage B,and 15 cases of stage C;they were 42-75(54.61±5.63)years old.Both groups were given routine intervention after the operation.The control group did postoperative music relaxation training;in addition,the experimental group did abdominal breathing training after the surgery.The degrees of postoperative pain,the levels of stress response,and the negative emotions were compared between the two groups.t test was applied.Results After the intervention,the scores of Visual Analogue Scale(VAS)and Brief Pain Assessment Scale(BPI)and level of neuropeptide Y(NPY)in the experimental group were significantly lower than those in the control group[(2.53±0.55)vs.(3.61±0.89),(10.35±1.90)vs.(13.26±2.24),and(135.58±15.21)ng/L vs.(159.15± 19.08)ng/L],while the level of calcitonin gene-related peptide(CGRP)in the experimental group was higher than that in the control group[(34.13±5.48)ng/L vs.(29.73±4.86)ng/L],with statistical differences(t=7.00,6.72,6.55,and 4.07;all P＜0.05).After the intervention,the levels of prostaglandin E2(PGE2),5-hydroxytryptamine(5-HT),substance P(SP),and cortisol(Cor)in the experimental group were lower than those in the control group[(95.38±9.27)μg/L vs.(106.12± 12.37)μg/L,(242.16±30.79)mmol/L vs.(282.13±36.67)mmol/L,(40.13±5.91)pg/L vs.(46.89± 6.75)pg/L,and(532.12±50.79)nmol/L vs.(603.60±57.21)nmol/L],with statistical differences(t=4.71,5.66,5.04,and 6.43;all P＜0.05).After the intervention,the scores of Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)in the experimental group were lower than those in the control group[(13.02±2.08)vs.(15.13±2.26)and(9.83±1.37)vs.(12.95±2.08)],while the level of dopamine(DA)in the experimental group was higher than that in the control group[(75.59± 7.25)ng/L vs.(67.39±6.78)ng/L],with statistical differences(t=4.66,8.50,and 5.60;all P＜0.05).Conclusion Relaxation therapy for patients with primary liver cancer complicated with portal hypertension after TIPS can relieve their pain,reduce their stress response level,and improve their bad mood.
万方数据
维普
