Research progress on the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer
陈晓琳 1杨贞2
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作者信息
1. 汕头大学医学院,汕头 515063;揭阳市人民医院妇科,揭阳 522000
2. 揭阳市人民医院妇科,揭阳 522000
折叠
摘要
宫颈癌为全球第四大恶性肿瘤,且发病率正在不断上升.高危型人乳头瘤病毒(high risk human papilloma virus,HR-HPV)持续感染被认为是宫颈癌的主要致病因素.自2019年开始,很多权威机构都建议采用HPV DNA检测作为宫颈癌初筛手段.但是,这种方法会筛查出大量HPV阳性的女性,因此,准确识别宫颈癌高风险人群,并实施有效的管理很有必要.近来有研究表明,HR-HPV可能是宫颈病变病情进展的一个参考指标,但它们之间的关系仍不明确.因此,本文旨在深入探讨HR-HPV载量与宫颈病变严重程度之间的关系,以期有助于宫颈癌的早期诊断和早期治疗.
Abstract
Cervical cancer is the fourth most common cancer worldwide,and its incidence is rising.The most important risk factor for cervical cancer is persistent high risk human papilloma virus(HR-HPV)infection.Many authorities in the world have recommended that HPV DNA testing has been a method of cervical cancer preliminary screening since 2019.However,this method screens out a large number of HPV-positive women,so it is necessary to accurately identify the high-risk groups of cervical cancer and implement effective managements.Recent studies have shown that HR-HPV load may be a reference marker for the progression of cervical lesions,but the relationship between them is still not clear.The aim of this study is to investigate the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer,and to improve the early diagnosis and treatment of cervical cancer.
关键词
高危型人乳头瘤病毒/病毒载量/宫颈上皮内病变/宫颈癌/进展
Key words
High risk human papilloma virus/HR-HPV load/Cervical intraepithelial neoplasia/Cervical cancer/Progress
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