宫颈癌为全球第四大恶性肿瘤,且发病率正在不断上升.高危型人乳头瘤病毒(high risk human papilloma virus,HR-HPV)持续感染被认为是宫颈癌的主要致病因素.自2019年开始,很多权威机构都建议采用HPV DNA检测作为宫颈癌初筛手段.但是,这种方法会筛查出大量HPV阳性的女性,因此,准确识别宫颈癌高风险人群,并实施有效的管理很有必要.近来有研究表明,HR-HPV可能是宫颈病变病情进展的一个参考指标,但它们之间的关系仍不明确.因此,本文旨在深入探讨HR-HPV载量与宫颈病变严重程度之间的关系,以期有助于宫颈癌的早期诊断和早期治疗.
Research progress on the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer
Cervical cancer is the fourth most common cancer worldwide,and its incidence is rising.The most important risk factor for cervical cancer is persistent high risk human papilloma virus(HR-HPV)infection.Many authorities in the world have recommended that HPV DNA testing has been a method of cervical cancer preliminary screening since 2019.However,this method screens out a large number of HPV-positive women,so it is necessary to accurately identify the high-risk groups of cervical cancer and implement effective managements.Recent studies have shown that HR-HPV load may be a reference marker for the progression of cervical lesions,but the relationship between them is still not clear.The aim of this study is to investigate the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer,and to improve the early diagnosis and treatment of cervical cancer.
High risk human papilloma virusHR-HPV loadCervical intraepithelial neoplasiaCervical cancerProgress
万方数据
维普
