Advances in single-cell RNA sequencing in secondary nephrosis
Diabetic nephropathy(DN)and lupus nephritis(LN)are the major secondary nephropathy and are important causes of end-stage renal disease(ESRD).Exploring the developmental process of secondary nephrosis is conducive to reducing the renal function damage.Kidney cells have the characteristics of high degree of differentiation and complex structure.Bulk RNA sequencing can only explore the average transcription level and relationship of one type of cells.In recent years,single-cell RNA sequencing(scRNA-seq)technology has developed rapidly.Its high throughput and unprecedented resolution make it possible to analyze the renal tissue,blood,and urine cell samples,to identify the new cell types and states,to draw the cell atlas,to unravel the complex mechanisms of kidney disease from the cellular level dimension,and to discover the biomarkers and cell specificity.This reviews focuses on the latest research advances in scRNA-seq in common secondary nephrosis.
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维普
