Predictive efficacy of serum TG/HDLC and SPP24 for cardiovascular events in hemodialysis patients
Objective To explore the efficacy of serum triglyceride/high density lipoprotein cholesterol(TG/HDLC)and secreted phosphoprotein 24(SPP24)in predicting cardiovascular events in hemodialysis patients.Methods A total of 159 patients undergoing maintenance hemodialysis admitted to Chang An Hospital from June 2020 to June 2022 were prospectively selected,including 88 males and 71 females,aged＞18 years,and cardiovascular events were followed up for 1 year.Forty-one patients with cardiovascular events were included in the cardiovascular event group,and 118 patients without cardiovascular events were included in the non-cardiovascular event group.Serum TG/HDLC and SPP24 levels were detected.t test,x2test,and logistic regression analysis model were used to analyze the factors affecting the occurrence of cardiovascular events in maintenance hemodialysis patients.Receiver operating characteristic curve(ROC)was used to analyze the efficacy of serum TG/HDLC and SPP24 in predicting cardiovascular events in maintenance hemodialysis patients.Results Multivariate logistic regression analysis showed that dialysis age(OR=4.586,95％CI 1.887-11.145),TG/HDLC(OR=3.904,95％C11.594-9.563),and SPP24 level(OR=0.308,95％CI 0.127-0.748)were the influencing factors for cardiovascular events in maintenance hemodialysis patients(all P＜0.05).ROC analysis results showed that the sensitivities of TG/HDLC,SPP24,and their combination in predicting cardiovascular events in maintenance hemodialysis patients were 70.73％(95％CI 54.26％-83.35％),68.29％(95％CI 51.78％-81.42％),and 82.93％(95％CI 67.35％-92.30％),respectively,the specificities were 70.34％(95％CI 61.12％-78.21％),75.42％(95％CI 66.48％-82.68％),and 89.83％(95％CI 82.56％-94.40％),respectively,and the areas under the curves were 0.733(95％CI 0.638-0.828),0.708(95％CI 0.597-0.819),and 0.894(95％CI 0.829-0.959),respectively.Conclusion Serum TG/HDLC combined with SPP24 can improve the predictive efficacy of cardiovascular events in maintenance hemodialysis patients.
HemodialysisCardiovascular eventsTriglyceride/high density lipoprotein cholesterolSecreted phosphoprotein 24Efficiency
万方数据
维普
