Clinical significance of MRI functional imaging combined with serology in distinguishing the nature of prostate lesions
Objective To explore the clinical significance of MRI functional imaging combined with serology in distinguishing the nature of prostate lesions.Methods A retrospective study was conducted on 120 suspected prostate cancer(PCa)patients admitted to Yan'an People's Hospital from July 2021 to July 2023,all male.All patients underwent routine 3.0T MRI scan,diffusion-weighted imaging(DWI),magnetic resonance spectroscopy(MRS),and pathological examination.Based on the pathological results,the patients were divided into a PCa group(53 cases)and a benign group(67 cases).The age of the PCa group was(63.19±4.72)years old,while the age of the benign group was(61.75±4.54)years old.Serum free prostate-specific antigen(fPSA)levels,total prostate-specific antigen(tPSA)levels,MRI functional imaging results,pathological results,and diagnostic efficacies of different examination methods were compared between the two groups.Independent sample t test and x2 test were used.Results The serum levels of fPSA and tPSA in the PCa group were higher than those in the benign group(both P＜0.05).The diagnostic sensitivity of routine MRI scanning was 69.81％(37/53),the specificity was 83.58％(56/67),and the accuracy was 77.50％(93/120).The diagnostic sensitivity of DWI was 75.47％(40/53),the specificity was 88.06％(59/67),and the accuracy was 82.50％(99/120).The diagnostic sensitivity of MRS was 73.58％(39/53),the specificity was 86.57％(58/67),and the accuracy was 80.83％(97/120).The diagnostic sensitivity of serology was 71.70％(38/53),the specificity was 86.57％(58/67),and the accuracy was 80.00％(96/120).The diagnostic sensitivity of their combination was 94.34％(50/53),the specificity was 83.58％(56/67),and the accuracy was 88.33％(106/120).The sensitivity and positive predictive value of combined diagnosis were higher than those of functional MRI imaging and serology alone,and the missed diagnosis rate was lower than that of functional MRI imaging and serology alone(all P＜0.05).Conclusion MRI functional imaging combined with serology has certain diagnostic value for PCa and can serve as an effective diagnostic method for distinguishing the nature of prostate lesions in clinical practice.
Prostate lesionsMRI functional imagingFree prostate specific antigenTotal prostate specific antigen
万方数据
维普
