Value of serum NSE,S-100β,and CRP/PA in predicting short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia
Objective To analyze the value of serum neuron specific enolase(NSE),S-100β,and C-reactive protein(CRP)/prealbumin(PA)in predicting short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia.Methods The clinical data of 130 patients with severe cerebral contusion complicated with cerebral hernia who received decompressive craniectomy in Xi'an Gaoxin Hospital from May 2020 to May 2023 were retrospectively analyzed,including 85 males and 45 females,with an age of(55.13±10.33)years old.The Glasgow Coma Scale(GCS)score was 3-8 points in 56 cases,and＞8 points in 74 cases.There were 79 cases of single brain contusion and 51 cases of multiple brain contusions.The patients'survival 30 days after operation was recorded.Twenty-six cases(20.00％)died in hospital and 104 cases(80.00％)were discharged successfully after treatment.Baseline data such as age and gender were collected in the two groups.Serum levels of NSE,S-100β,CRP,and PA were detected by enzyme linked immunosorbent assay(ELISA)and electrochemiluminescence method upon admission.The data were analyzed by t and x2 tests.Multivariate logistic regression analysis was used to analyze the risk factors of short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia,and the values of serum NSE,S-100β,and CRP/PA levels in predicting short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia were observed by the receiver operating characteristic curve(ROC).Results The proportions of the patients with GCS score of 3-8,multiple cerebral contusion,and use of anticoagulants 1 week before admission and serum levels of NSE,S-100β,and CRP/PA in the death group were higher than those in the survival group(all P＜0.05).Multivariate logistic regression analysis showed that GCS score at admission,site of cerebral contusion,use of anticoagulant drugs 1 week before admission,and serum NSE,S-100β,and CRP/PA levels were all risk factors for short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia(all P＜0.05).ROC analysis confirmed that serum NSE,S-100β,and CRP/PA levels could be used to predict short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia,with the area under the curve of 0.795,0.753,and 0.801,respectively(all P＜0.05).Conclusions GCS score at admission,site of cerebral contusion,use of anticoagulant drugs 1 week before admission,and serum NSE,S-100β,and CRP/PA levels are all risk factors for short-term in-hospital death in patients with severe cerebral contusion complicated with cerebral hernia.Clinical screening should be focused on high-risk patients with the above indicators,and timely interventions should be taken.
Severe cerebral contusionCerebral herniaNeuron specific enolaseS-100βC-reactive proteinPrealbumin
万方数据
维普
