Objective To explore the effect of autologous platelet-rich plasma in the treatment of chronic refractory wounds.Methods From July 2022 to June 2023,64 patients with chronic refractory wounds in the People's Hospital of Xiangxiang City were divided into two groups by drawing lots with two-color balls.The patients with red balls were selected as the control group,and the patients with green balls as the observation group.In the control group,there were 18 males and 14 females;the age was 23-77(46.48±3.34)years old;the course of disease was 2-22(13.45±2.12)months;the wound area was 2-35(16.23±3.12)cm2.In the observation group,there were 19 males and 13 females;the age was 23-78(46.12±3.12)years old;the course of disease was 2-24(14.67±2.08)months;the wound area was 2-33(16.12±3.07)cm2.The control group was treated with traditional therapy,while the observation group was treated with autologous platelet-rich plasma.The recovery conditions(wound healing time,infection control time,hospital stay,and granulation tissue growth thickness),pain scores[Visual Analogue Scale(VAS)score],scar hyperplasia scores[Vancouver Scar Scale(VSS)score],wound recovery scores[Bates-Jensen Wound Assessment Tool(BWAT)score],wound healing levels[Pressure Ulcer Scale for Healing(PUSH)score],levels of inflammatory factors[C-reactive protein(CRP),interleukin-1β(IL-1β),and procalcitonin(PCT)],and qualities of life[36-item Short Form(SF-36)score]of the two groups were compared.Independent sample t test and x2 test were used.Results The wound healing time,infection control time,hospital stay,and granulation tissue growth thickness in the observation group were(29.25±2.68)d,(10.12±2.48)d,(30.24±2.48)d,and(3.48±0.78)mm,respectively,which were superior to those in the control group[(35.26±2.74)d,(12.15±2.78)d,(36.59±3.12)d,and(1.57±0.45)mm](t=8.870,11.998,3.082,and 9.013,all P＜0.05).After treatment,the VAS and VSS scores of the observation group were(3.12±0.56)points and(2.41±0.63)points,which were lower than those of the control group[(4.45±0.78)points and(4.15±1.05)points](t=7.835 and 8.038,both P＜0.05).After treatment,the BWAT and PUSH scores of the observation group were(21.12± 0.56)points and(8.35±2.04)points,which were lower than those of the control group[(27.45± 0.78)points and(10.29±2.08)points](t=37.292 and 3.763,both P＜0.05).After treatment,the levels of CRP[(15.65±6.21)mg/L],IL-1β[(26.58±7.89)µg/L],and PCT[(1.89±0.48)ng/L]in the observation group were lower than those in the control group[(23.26±6.78)mg/L,(33.48± 8.14)µg/L,and(3.15±0.78)μg/L](t=4.682,3.443,and 7.782,all P＜0.05).After treatment,the general health status of life quality in the observation group was better than that in the control group[(79.46±8.45)points vs.(72.78±8.26)points](t=3.198,P＜0.05).Conclusion Autologous platelet-rich plasma is effective in the treatment of chronic refractory wounds,which is helpful for wound healing,can effectively relieve the patients'pain,reduce the inflammatory reaction,promote the appearance improvement,and comprehensively improve their quality of life,with significant clinical value.
Chronic refractory woundsAutologous platelet-rich plasmaRecovery statusPainScar hyperplasiaWound recoveryWound healingInflammatory factorsQuality of life
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