Objective To explore the role of empathy technology based on bio-psycho-social system in the perioperative period of intracranial aneurysm.Methods This study was a randomized controlled study.A total of 105 patients with intracranial aneurysm treated by interventional embolization in Wuxi Second People's Hospital from February 2020 to February 2022 were prospectively selected as the research objects,and they were divided into an observation group[52 cases,27 males and 25 females,aged(63.72±8.98)years,with the diameter of the aneurysm of(6.02±1.23)mm]and a control group[53 cases,30 males and 23 females,aged(62.36± 8.75)years,with the diameter of the aneurysm of(5.86±1.17)mm]by the random number table method.The patients in the control group were given conventional nursing mode,and the patients in the observation group were given empathy technology based on bio-psycho-social system on the basis of the control group.The adverse emotions and treatment compliance before and after nursing,postoperative rehabilitation indexes,complications,and satisfaction of patients and their families were compared between the two groups.t test was used for the measurement data,x2 test and Fisher exact probability method were used for the count data.Results The scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)[(39.16±7.96)points,(48.13±9.75)points,(42.58±8.63)points,and(49.62±9.96)points]in the two groups 7 d after surgery were lower than those before surgery[(58.12±11.89)points,(59.56±12.31)points,(57.78±11.69)points,and(56.52± 11.45)points](all P<0.05).Moreover,those in the observation group[(39.16±7.96)points and(42.58±8.63)points]were lower than those in the control group[(48.13±9.75)points and(49.62± 9.96)points](both P<0.05).The hospitalization time in the observation group[(9.13±1.95)d]was shorter than that in the control group[(11.26±2.32)d](P<0.05).There were no statistically significant differences in the Glasgow Outcome Scale(GOS)score[(4.36±0.86)points vs.(4.62±0.92)points]and complication rate[9.62%(5/52)vs.22.64%(12/53)]between the two groups(both P>0.05).Before discharge,the scores of medication adherence[(92.23±20.50)points and(83.46± 18.55)points],daily exercise[(89.58±19.91)points and(80.62±17.92)points],diet management[(90.69±14.14)points and(81.45±18.10)points],and adverse management[(87.69±19.49)points and(78.45±17.43)points]in the two groups were higher than those before nursing[(58.32±12.96)points,(56.16±12.48)points,(62.78±13.95)points,(61.82±13.74)points,(60.68±13.48)points,(59.21±13.16)points,(49.68±11.04)points,and(50.21±11.16)points](all P<0.05).Moreover,those in the observation group[(92.23±20.50)points,(89.58±19.91)points,(90.69±14.14)points,and(87.69±19.49)points]were higher than those in the control group[(83.46±18.55)points,(80.62± 17.92)points,(81.45±18.10)points,and(78.45±17.43)points](all P<0.05).The satisfaction scores of patients and their families in the observation group[(96.25±19.25)points and(95.26±19.05)points]were higher than those in the control group[(88.05±17.61)points and(87.45±17.49)points](both P<0.05).Conclusion Empathy technology based on the bio-psycho-social system can effectively improve the clinical efficacy in patients with intracranial aneurysm in the perioperative period,improve their anxiety and depression,improve the treatment compliance and the satisfaction of patients and their families,and reduce the incidence of postoperative complications.