辣椒素受体在腹泻型肠易激综合征发病中的作用
Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome
崔筱 1刘亮2
作者信息
- 1. 山东第一医科大学研究生院山东省医学科学院,济南 250011;山东第一医科大学附属中心医院消化内科,济南 250011
- 2. 山东第一医科大学附属中心医院消化内科,济南 250011
- 折叠
摘要
腹泻型肠易激综合征(diarrheal irritable bowel syndrome,IBS-D)是常见的功能性胃肠疾病之一,其典型症状为间断性腹痛、腹泻.IBS-D有病程长、症状易反复等特点,是一种严重影响患者生活质量的慢性功能性疾病.目前,研究认为,其发病机制与内脏高敏感、脑-肠轴失衡、肠道菌群失调等因素相关.有研究表明,辣椒素受体参与其中并发挥了重要作用.本文就辣椒素受体参与内脏高敏感、脑-肠轴失衡、肠道菌群失调发生的具体机制作一综述,以期为探索IBS-D发病机制及治疗靶点提供参考.
Abstract
Diarrheal irritable bowel syndrome(IBS-D)is one of the common functional gastrointestinal disorders characterized by intermittent abdominal pain and diarrhea.IBS-D is a chronic functional disease with a long course and easy recurrence of symptoms,and seriously affects the patients'quality of life.At present,it is believed that its pathogenesis is closely related to factors such as visceral hypersensitivity,brain-gut axis imbalance,intestinal flora imbalance,etc.Current studies have shown that capsaicin receptors are involved and play an important role.In this article,the specific mechanism of capsaicin receptors involved in visceral hypersensitivity,brain-gut axis imbalance,and intestinal flora imbalance is reviewed,so as to provide references for exploring the pathogenesis and therapeutic targets of IBS-D.
关键词
腹泻型肠易激综合征/辣椒素受体/内脏高敏感/脑-肠轴/肠道菌群/综述Key words
Diarrheal irritable bowel syndrome/Capsaicin receptors/Visceral hypersensitivity/Brain-gut axis/Intestinal flora/Review引用本文复制引用
基金项目
山东省医药卫生科技发展计划(202003030878)
出版年
2024
国家科技期刊平台
NSTL
万方数据