Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome
Diarrheal irritable bowel syndrome(IBS-D)is one of the common functional gastrointestinal disorders characterized by intermittent abdominal pain and diarrhea.IBS-D is a chronic functional disease with a long course and easy recurrence of symptoms,and seriously affects the patients'quality of life.At present,it is believed that its pathogenesis is closely related to factors such as visceral hypersensitivity,brain-gut axis imbalance,intestinal flora imbalance,etc.Current studies have shown that capsaicin receptors are involved and play an important role.In this article,the specific mechanism of capsaicin receptors involved in visceral hypersensitivity,brain-gut axis imbalance,and intestinal flora imbalance is reviewed,so as to provide references for exploring the pathogenesis and therapeutic targets of IBS-D.
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