Effect of concentrated growth factors combined with guided bone regeneration in repairing tissue defects after anterior cystic apical surgery
Objective To explore the effect of concentrated growth factors(CGF)combined with guided bone regeneration(GBR)in repairing tissue defects after anterior cystic apical surgery.Methods Eighty patients with tissue defects after anterior cystic apical surgery treated at Xi'an No.3 Hospital from January 2020 to January 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 40 cases in each group.There were 24 males and 16 females in the control group;they were(46.91±8.02)years old.There were 19 males and 21 females in the observation group;they were(46.58±7.94)years old.The control group were treated with GBR,while the observation group with CGF and GBR.The periodontal probing depths(PD),clinical attachment loss(CAL),gingival recession(GR),aesthetic restoration effects[pink esthetic score(PES)and white esthetic score(WES)],and overall satisfaction rates were compared between the two groups.t and x2 tests were applied.Results There were no statistical differences in PD,CAL,and GR between the two groups before the operation(all P＞0.05).After the operation,the PD,CAL,and GR in the observation group were better than those in the control group[(4.51±1.06)mm vs.(5.33±1.01)mm,(5.08±1.13)mm vs.(6.84±1.42)mm,and(2.97±0.80)mm vs.(2.49±0.87)mm],with statistical differences(t=3.542,6.134,and 2.569;all P＜0.05).Three months after the treatment,the scores of near middle gingival papilla,far middle gingival papilla,labial gingival margin curvature and height,and root convexity/soft tissue color and texture and total score of PES in the observation group were higher than those in the control group[(1.84±0.57)vs.(1.32±0.42),(1.96± 0.64)vs.(1.41±0.51),(1.86±0.68)vs.(1.35±0.66),(1.97±0.65)vs.(1.46±0.52),(1.92±0.67)vs.(1.49± 0.54),and(9.55±1.45)vs.(7.03±1.38)],with statistical differences(t=4.288,4.251,3.404,3.875、3.160,and 7.962;all P＜0.05).Three months after the treatment,the scores of crown shape,crown contour,crown color,and crown surface texture,and transparency/individualization and total score of WES in the observation group were higher than those in the control group[(1.94±0.61)vs.(1.68± 0.52),(1.95±0.50)vs.(1.47±0.54),(1.86±0.33)vs.(1.43±0.46),(1.91±0.49)vs.(1.52±0.41),(1.93± 0.56)vs.(1.56±0.54),(9.59±1.26)vs.(7.66±1.34)],with statistical differences(t=2.051,4.125,4.804,3.861,3.008,and 6.636;all P＜0.05).The overall satisfaction rate in the observation group was higher than that in the control group[97.50％(39/40)vs.72.50％(29/40)],with a statistical difference(x2=9.804;P=0.002).Conclusion CGF combined with GBR repairing tissue defects after anterior cystic apical surgery is clinically effective,may provide the patients with biomaterial and a new regeneration strategy and a choice in periodontal tissue reconstruction at department of oral and maxillofacial surgery.
Anterior teethConcentrated growth factorsApical surgery
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