Curative effect of Huayu Fuming Decoction combined with calcium oxybenzenesulfonate capsules for patients with early diabetic retinopathy
Objective To explore the curative effect of Huayu Fuming Decoction combined with calcium oxybenzenesulfonate capsules for patients with diabetic retinopathy(DR).Methods One hundred and four patients with DR treated at Ankang Hospital of Traditional Chinese Medicine from May 2020 to May 2023 were selected for the randomized control trial,and were divided into a control group(52 cases)and a treatment group(52 cases)by the random number table method.There 29 males and 23 females in the control group;they were(45.91±1.83)years old.There were 27 males and 25 females in the treatment group;they were(45.82±1.79)years old.The control group were treated with calcium oxybenzenesulfonate capsules,0.5 g each time,3 times a day,and the treatment group with calcium oxybenzenesulfonate capsules and Huayu Fuming decoction,200 ml was 1 dose,1 dose per day,for 1 month.The Chinese medicine syndromes,scores of Chinese version of Quality of Life Scale for Low Vision(CLVQOL),macular thicknesses,blood spot areas,levels of blood glucose indicators,and serum levels of vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF),and interleukin-1(IL-1)were compared between the two groups before and after treatment.The efficacies the and adverse reactions in both groups were statistically analyzed.t and x2 tests were used for the statistical comparison.Results The total effective rate of the treatment group was higher than that of the control group[96.15％(50/52)vs.(82.69％(43/52),with a statistical difference(x2=4.98,P=0.026).After the treatment,the scores of traditional Chinese medicine syndrome and CLVQOL in the treatment group were better than those in the control group[(7.28±1.36)vs.(11.71±1.50)and(113.25±10.48)vs.(89.76±8.17)J,with statistical differences(t=15.78 and 12.75;both P＜0.05).After the treatment,the macular thickness and the area of blood stains decreased in both groups.After the treatment,the macular thickness and blood spot area in the treatment group were lower than those in the control group[(306.42±11.09)μm vs.(355.37±13.17)μm and(1.04±0.26)mm2 vs.(1.85±0.37)mm2],with statistical differences(t=20.50 and 12.92;both P＜0.001).After the treatment,the levels of fasting blood glucose(FBG),2 h fasting blood glucose(2 hFBG),and glycosylated hemoglobin(HbAlc)in the treatment group were lower than those in the control group[(6.30±1.18)mmol/L vs.(7.35± 1.24)mmol/L,(15.40±4.25)mmol/L vs.(17.35±4.32)mmol/L,and(3.76±0.95)μmol/L vs.(5.41± 1.12)μmol/L],with statistical differences(t=4.42,2.32,and 8.10;all P＜0.05).After the treatment,the levels of VEGF,PDGF,and IL-1 in the treatment group were lower than those in the control group[(88.75±14.03)μg/L vs.(136.22±17.41)μg/L,(4.43±0.97)μg/L vs.(6.12±1.08)μg/L,(21.06± 4.05)ng/L vs.(25.42±4.57)ng/L],with statistical differences(t=15.31,8.40,and 3.97;all P＜0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group[3.85％(2/52)vs.15.38％(8/52)],with a statistical difference(x2=3.98;P＜0.05).Conclusion Huayu Fusing Decoction combined with calcium oxybenzenesulfonate capsules for patients with DR has ideal effect,and can improve their traditional Chinese medicine syndromes and quality of life,and reduce macular injury,blood glucose level,and serum levels of VEGF,PDGF,and IL-1,with a low incidence of adverse reactions and good safety,so it is worthy of promotion.
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