Estradiol valerate tablets combined with metformin for infertility patients
Objective To explore the effect of estradiol valerate tablets combined with metformin for infertility patients.Methods Eighty-six infertility patients treated at Ankang Central Hospital from July 2021 to September 2022 were selected for the randomized controlled trial,and were divided into a control group and a study group by the random number table method,with 43 cases in each group.The control group were(29.34±1.81)years old;their body mass index was(27.09±1.63)kg/m2;their disease course was(1.62±0.84)years.The study group were(28.71± 1.67)years old;their body mass index was(28.11±1.72)kg/m2;their disease course was(1.58± 0.92)years.The control group took valerate estradiol tablets;in addition,the study group orally took metformin.Both groups were treated for 8 weeks.The hormone levels[estradiol(E2),luteinizing hormone(LH),and serum progesterone(SP)],levels of oxidative stress indicators[advanced oxidation protein products(AOPP)and glutathione peroxidase(GSH-Px)],endometrial thicknesses,and follicle diameters before and after the treatment,ovulation rates,and pregnancy outcomes after 1-year follow-up were compared between the two groups.t test was used for the measurement data,and x2 test for the count data.Results The hormone levels,oxidative stress indicators,endometrial thickness,and follicle diameter were better after than before the treatment in both groups.After the treatment,the levels of E2,SP,GSH-Px,LH,and AOPP,endometrial thickness,and follicle diameter in the study group were better than those in the control group[(92.17±8.79)ng/L vs.(79.98±7.67)ng/L,(19.37±2.76)μg/L vs.(14.95±1.94)μg/L,(182.23±18.75)mg/L vs.(169.87±14.98)mg/L,(9.89± 1.41)IU/L vs.(11.86±1.38)IU/L,(36.32±3.67)mg/L vs.(51.89±3.32)mg/L,(11.87±1.86)mm vs.(9.82±1.63)mm,and(11.09±1.06)mm vs.(9.87±1.01)mm],with statistical differences(t=6.852,8.591,3.377,6.548,20.631,5.435,and 5.464;all P＜0.05).There was no statistical difference in the early pregnancy miscarriage rate between the study group and the control group[2.33％(1/43)vs.6.98％(3/43);x2=1.049;P=0.306)].The ovulation rate and pregnancy rate in the study group were higher than those in the control group[86.05％(37/43)vs.60.47％(26/43)and 67.74％(29/43)vs.44.19％(19/43)],with statistical differences(x2=7.182 and 4.715;both P＜0.05).Conclusion Valerate estradiol tablets combined with metformin for infertility patients can improve their endometrial thickness,follicle diameter,hormonal balance,oxidative stress,and ovulation and pregnancy rates.
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