Value of LTBP-2 combined with cardiopulmonary ultrasound in predicting short-term prognosis of elderly patients with acute myocardial infarction
Objective To explore the predictive value of latent transforming growth factor-β binding protein-2(LTBP-2)combined with cardiopulmonary ultrasound(CPUS)in short-term prognosis of elderly patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A retrospective analysis was performed on 116 patients with AMI who underwent PCI in Xi'an Gaoxin Hospital during May 2020 and March 2023.There were 60 males and 56 females,aged 60-80 years,Killip grade:37 cases of grade I,51 cases of gradeⅡ,and 28 cases of grade Ⅲ.The level of LTBP-2 and CPUS were measured.The patients were followed up for 3 months after operation to observe the prognosis,and they were divided into a good prognosis group and a bad prognosis group.The clinical data,LTBP-2 levels,and CPUS parameters of the two groups were compared.The influencing factors of major adverse cardiac events(MACE)after PCI in AMI patients were analyzed by multifactor logistic regression analysis,and the predictive value of LTBP-2 combined with CPUS in short-term prognosis was analyzed by the receiver operating characteristic curve(ROC).x2 test and independent sample t test were performed.Results The incidence of poor short-term prognosis in elderly AMI patients after PCI was 26.72％(31/116).The LTBP-2,early diastolic peak velocity of the mitral valve inflow/early diastolic peak velocity of the mitral valve annulus(E/e'),left atrial volume index(LVAI),number of B lines,time from onset to interventional treatment,and proportion of severe coronary lesions in the poor prognosis group were all higher than those in the good prognosis group,and the left ventricular ejection fraction(LVEF)was lower than that in the good prognosis group(all P＜0.05).The results of multivariate analysis showed that LTBP-2(OR=3.221,95％CI:1.993-5.206),number of B-lines(OR=3.182,95％CI:1.663-6.087),degree of coronary lesions(OR=1.487,95％CI:1.082-2.043)were independent risk factors for prognosis,and LVEF(OR=0.328,95％CI:0.157-0.681)was an independent protective factor(all P＜0.05).ROC analysis results showed that the sensitivities of LTBP-2,LVEF,number of B-lines,and their combination in predicting the short-term prognosis were 71.00％,74.20％,67.70％,and 87.10％,the specificities were 72.90％,76.50％,71.80％,and 91.80％,and the areas under the curves were 0.795,0.816,0.769,and 0.932,respectively(all P＜0.05).Conclusion LTBP-2 combined CPUS can predict the short-term prognosis of elderly AMI patients after PCI.
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