Effect of Qili Qiangxin capsules combined with rhBNP on patients with heart failure after acute myocardial infarction
Objective To investigate the effects of Qili Qiangxin capsules combined with recombinant human brain natriuretic peptide(rhBNP)on the cardiac function and expressions of angiotensin Ⅱ(Ang Ⅱ),Periostin,and growth arrest-specific protein 6(GAS6)in patients with heart failure after acute myocardial infarction.Methods A total of 82 patients with heart failure after acute myocardial infarction admitted to Liaocheng Third People's Hospital from April 2021 to April 2023 were simply randomly divided into two groups.In the control group,there were 19 males and 22 females,aged(59.35±8.64)years,7 cases of grade Ⅱ,18 cases of grade Ⅲ,and 16 cases of gradeⅣ.In the observation group,there were 20 males and 21 females,aged(60.27±9.12)years,9 cases of grade Ⅱ,19 cases of grade Ⅲ,and 13 cases of grade Ⅳ.The control group received 1.5 μg/kg of rhBNP treatment for 7 days,and the observation group received oral administration of Qili Qiangxin capsules on the basis of the control group for 21 days(1.2 g/time,3 times/day).The therapeutic effects,cardiac function[left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),and left ventricular end-diastolic diameter(LVEDD)],Ang Ⅱ,Periostin,and GAS6 levels before treatment and 21 days after treatment,and adverse reactions of the two groups were compared.t test and x2 test were performed.Results The total effective rate of the observation group was higher than that of the control group[92.68％(38/41)vs.75.61％(31/41)](P＜0.05).After treatment,the LVEF of the observation group[(54.56±5.15)％]was higher than that of the control group[(46.32±5.44)％],while the LVEDD[(42.34±6.18)mm],LVESD[(37.32±4.52)mm],Ang Ⅱ[(112.37±9.58)ng/L],Periostin[(89.47±9.25)ng/L],and GAS6[(13.41±3.68)μg/L]were lower than those of the control group[(51.17±5.26)mm,(40.92±4.11)mm,(118.13±9.61)ng/L,(98.54±9.72)ng/L,and(15.72±3.21)μg/L](all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group[12.20％(5/41)]and the control group[17.07％(7/41)](P＞0.05).Conclusion The combination of Qili Qiangxin capsules combined with rhBNP has a significant therapeutic effect on heart failure after acute myocardial infarction,improving the heart function and reducing the Ang Ⅱ,Periostin,and GAS6 levels,which can be widely promoted in clinical practice.
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