Curative effect of metoprolol tartrate combined with amiodarone on arrhythmia in acute myocardial infarction
Objective To explore the curative effect of metoprolol tartrate combined with amiodarone on arrhythmia in acute myocardial infarction.Methods The data of 223 patients with acute myocardial infarction and arrhythmia who were admitted to Xianyang Rainbow Hospital from July 2020 to July 2022 were analyzed retrospectively.The patients treated with amiodarone(intravenous drip with 4 ml of amiodarone hydrochloride injection into glucose injection+oral amiodarone hydrochloride tablets 0.2 g/time,3 times/day)and those treated with amiodarone combined with metoprolol tartrate(oral metoprolol tartrate tablets,25 mg/time,twice a day)were included in the control group(100 cases)and the combination group(123 cases),respectively.Both groups received treatment for 1 month.In the control group,there were 48 males and 52 females,aged(52.67±13.42)years,66 patients with cardiac function grade Ⅱ and 34 patients with grade Ⅲ.In the combination group,there were 71 males and 52 females,aged(51.92±13.56)years,86 patients with grade Ⅱ and 37 patients with grade Ⅲ.The curative effect,the cardiac function and levels of heart rate variability indices before and after treatment,and the occurrence of arrhythmia and drug-related adverse reactions were compared between the two groups.t test and x2 test were used.Results The total effective rate of the combination group was 95.12％(117/123),while that of the control group was only 86.00％(86/100),with a statistically significant difference between the two groups(P＜0.05).After treatment,the cardiac function indexes such as left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),heart rate(HR),and B-type natriuretic peptide(BNP)were significantly improved in both groups(all P＜0.05).After treatment,the LVEDD,LVESD,HR,and BNP in the combination group were lower than those in the control group,and the LVEF was higher than that in the control group,with statistically significant differences(all P＜0.05).After treatment,the root-mean-square of normal continuous sinus RR interval difference(rMSSD)decreased significantly,while the standard deviation of normal sinus RR intervals(SDNN),percentage of the number of adjacent RR intervals with an interval difference greater than 50 ms(PNN50),and mean standard deviation of sinus RR interval every 5 min within 24 h(SDANN)increased significantly in both groups(all P＜0.05).After treatment,the improvements of the above indexes of heart rate variability in the combination group were significantly greater than those in the control group(all P＜0.05).The incidences of arrhythmia and drug-related adverse reactions in the combination group[1.63％(2/123)and 5.69％(7/123)]after treatment were lower than those in the control group[11.00％(11/100)and 12.00％(12/100)],and there was a statistically significant difference in the incidence of arrhythmia only(P＜0.05).Conclusion Applying metoprolol tartrate combined with amiodarone to treat patients with acute myocardial infarction and arrhythmia can improve the heart rate variability,alleviate the cardiac injury,and reduce the occurrence of arrhythmia,with significant curative effect.
Metoprolol tartrateAmiodaroneAcute myocardial infarctionArrhythmiaObservation of curative effect
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