Research progress of Wnt signaling pathway in acute myocardial infarction
Wnt signaling pathway is a signal transduction pathway by which ligand protein Wnt binds to membrane protein receptors to stimulate downstream signaling molecules to produce cascade reactions.Wnt signaling pathway is a key pathway to regulate cell growth,proliferation,and differentiation.After acute myocardial infarction(AMI),the regeneration capacity of cardiomyocytes is limited,the fibroblasts multiply greatly,and the scar tissue is formed.Myocardial remodeling leads to decreased left ventricular function.Therefore,promoting myocardial regeneration and reducing scar area are of great significance for improving cardiac function after myocardial infarction.Wnt signaling pathway is involved both in normal cardiomyocytes and in the formation and development of cardiovascular diseases.The study on the role of Wnt signaling pathway in AMI can provide a new basis for the treatment of AMI.In this paper,we review the research progress of Wnt signaling pathway in the development of AMI.
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