m6A and m5C methylation modification affects the initiation and development of cancers by regulating cellular proliferation and metastasis
So far,more than 170 chemical modifications have been found in RNA.RNA methylation modification is an important post-transcriptional regulation process.N6-methyladenosine(m6A)and 5-methylcytosine(m5C)are ubiquitous in eukaryotes and prokaryotes.Additionally,more and more attention has been paid to the exploration of RNA methylation within regulating gene expression and regulating the cellular biological activity in the tumor cells.Furthermore,some known cell signal pathways involved in cellular proliferation and metastasis are closely related to cancers immunity and metabolic regulation,and these signal pathways play an important role in regulating organ size,tissue regeneration,and stem cell self-renewal,which ultimately affects the initiation and development of tumors.In this review,we discuss that the m6A and m5C methylation regulate the occurrence and development of cancers through some popular pathways in human cancers,which provides a new theoretical basis for understanding and seeking new therapeutic disease approaches.
RNA methylation modificationSignal pathwaysm6Am5CInitiation and development of cancersProgress
国家科技期刊平台
NSTL
万方数据
