Effect of drug coated balloon dilation and angioplasty on patients with in-stent restenosis of the femoral popliteal artery
Objective To explore the clinical effect of drug coated balloon dilation and angioplasty for patients with in-stent restenosis of the femoral popliteal artery.Methods A total of 96 patients with in-stent restenosis of the femoral popliteal artery,who were planned to undergo surgical treatment in Department of Vascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University from June 2019 to December 2022,were selected as the research subjects.They were divided into a study group and a control group with 48 cases in each group using the random number table method.In the study group,there were 28 males and 20 females,aged(64.1±6.7)years,and the length of lesion was(14.3±4.1)cm.In the control group,there were 33 males and 15 females,aged(62.5±7.2)years,and the length of lesion was(13.8±3.3)cm.The study group was treated with drug coated balloon dilation and angioplasty,while the control group was treated with conventional balloon technique.The changes in ankle-brachial index(ABI),minimum target vessel lumen diameter(MLD),long-term lumen loss(LLL),primary patency rate,Rutherford grade,intermittent claudication distance,and coagulation function were compared between the two groups before and after treatment.Statistical methods used were repeated measure ANOVA,independent sample t test,x2 test,and rank sum test.Results The ABI values of the two groups 3 months,6 months,and 12 months after surgery were higher than those before surgery;the ABI value of the study group 12 months after surgery was higher than that of the control group[(0.86±0.11)vs.(0.75± 0.14)],with a statistically significant difference(t=4.28,P＜0.05).The MLD value of the study group was higher than that of the control group 12 months after surgery[(2.85±0.46)mm vs.(2.53±0.51)mm],with a statistically significant difference(t=3.23,P＜0.05).The LLL values of the study group 6 months and 12 months after surgery were lower than those of the control group[(4.56±1.80)％vs.(5.71± 1.92)％,(13.37±2.60)％vs.(19.68±3.81)％],with statistically significant differences(t=-3.03 and-9.48,both P＜0.05).The Rutherford grade of the study group was lower than that of the control group 12 months after surgery,with a statistically significant difference(Z=-2.19,P＜0.05).Three months after surgery,the prothrombin time(PT)and thrombin time(TT)of the study group were higher than those of the control group[(13.41±0.31)s vs.(13.23±0.34)s,(16.92±0.88)s vs.(16.46± 0.95)s],with statistically significant differences(t=2.71 and 2.46,both P＜0.05).Conclusion The treatment of in-stent restenosis of the femoral popliteal artery using drug coated balloon dilation and angioplasty is more beneficial than conventional stents in maintaining continuous vascular patency,alleviating the patients'blood hypercoagulable state,and better improving the treatment effect.
Femoral arteryPopliteal arteryStentRestenosisDrug coated balloon dilation and angioplasty
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