Correlation analysis between serum uric acid and carotid intima-media thickness in patients with hypertension
Objective To analyze the relationship between serum uric acid(SUA)and carotid intima-media thickness(CIMT)in patients with hypertension.Methods A retrospective study was conducted to select 110 patients diagnosed with hypertension in Xi'an Hospital of Traditional Chinese Medicine from March to October 2020.Among them,there were 60 patients with simple hypertension[HT group,31 males and 29 females,aged(51.59±10.84)years]and 50 patients with hypertension combined with hyperuricemia[HT+HU group,23 males and 27 females,aged(52.27±10.12)years].In addition,40 healthy adults were selected[healthy control group,20 males and 20 females,aged(51.23±9.43)years].The differences of blood pressure,body mass index(BMI),triglyceride,total cholesterol,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),SUA,and CIMT among all the groups were compared,and the correlation between SUA and CIMT was analyzed.The statistical methods were one-way ANOVA,x2 test,partial correlation analysis,and multiple linear regression analysis.Results There were no statistically significant differences in the gender,age,heart rate,smoking,total cholesterol,triglyceride,HDL-C,and LDL-C among the 3 groups(all P＞0.05).The SUA level in the HU+HT group was higher than that in the control group and the HT group[(496.52±74.82)μmol/L vs.(253.42±80.46)μmol/L vs.(267.78±75.72)μmol/L],with a statistically significant difference(F=156.14,P＜0.05).The systolic blood pressure and diastolic blood pressure in the HT group and the HU+HT group were higher than those in the control group[(164.72±12.86)mmHg(1 mmHg=0.133 kPa)vs.(165.87±12.96)mmHg vs.(106.75±7.46)mmHg,(98.82±6.56)mmHg vs.(98.78±6.85)mmHg vs.(73.68±4.66)mmHg],with statistically significant differences(F=366.07 and 239.34,both P＜0.05).The CIMT of the HU+HT group and the HT group were higher than that of the control group,and the CIMT of the HU+HT group was higher than those of the HT group and the control group[(1.02±0.18)mm vs.(0.85±0.19)mm vs.(0.60±0.11)mm],with a statistically significant difference(F=68.95,P＜0.05).Partial correlation analysis showed that SUA level was positively correlated with CIMT level in the HU+HT group(r=0.42,P＜0.05).Multiple linear regression analysis showed that SUA level was an independent risk factor for CIMT in hypertensive patients(P＜0.05).Conclusions The thickening of CIMT is significant in patients with hypertension combined with hyperuricemia,and the SUA level in patients with hypertension is closely related to CIMT.When patients with hypertension are combined with hyperuricemia,the course of cardiovascular diseases such as atherosclerosis is further aggravated.
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