Objective To explore the relationship between lipoprotein-associated phospholipase A2(Lp-PLA2)gene polymorphism and the risk of hypertensive large artery atherosclerotic stroke(LAAS),in order to identify the genetic susceptibilities and new therapeutic targets.Methods A prospective study was conducted on 106 hypertensive patients hospitalized for LAAS at the Department of Neurology,Yulin Xingyuan Hospital from January 2020 to January 2023,forming the case group.A control group of 160 hypertensive patients,matching in the general data,was selected from the physical examination center.The control group included 80 males and 80 females,with an age of(74.72±6.60)years old,and the case group included 53 males and 53 females,with an age of(75.07±7.13)years old.The gene polymorphism of Lp-PLA2 was examined,and its association with the risk of hypertensive LAAS was analyzed using logistic regression analysis.Independent sample t test and x2 test were used.Results There was a statistically significant difference in the frequency of R92H site RR,RH,and HH genotype between the case group and the control group[66.04％(70/106)vs.10.00％(16/160),16.98％(18/106)vs.45.00％(72/160),16.98％(18/106)vs.45.00％(72/160)](x2=91.516,P＜0.001).There was a statistically significant difference in the frequency of R and H alleles between the case group and the control group[74.53％(158/212)vs.32.50％(104/320),25.47％(54/212)vs.67.50％(216/320)](x2=90.119,P＜0.001).Logistic regression analysis showed that R92H(RR)genotype was a risk factor for hypertensive LAAS(OR=38.212,95％CI 9.959-146.616,P＜0.001).Conclusion The R92H site mutation in the Lp-PLA2 gene is an important genetic risk factor for hypertensive patients developing LAAS,playing a key role in the progression of the disease.
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