It gradually develops from superficial gastritis to gastric cancer,and this sequential process is called Correa cascade.In the Correa cascade,the involvement of macrophages was found both in the inflammatory microenvironment at the inflammatory stage and in the tumor microenvironment where tumor cells are located.Polyamines,especially putreamine,are also closely related to the occurrence and development of gastric cancer,and the metabolism of polyamines can affect the polarization of macrophages.In recent years,the relationship between putrescine and gastric"inflammation and cancer transformation"and the intervention of the occurrence and development of cancer by regulating the polarization of macrophages have become research hotspots.This article reviews the related researches on gastric cancer,putrescine,and macrophage polarization in recent years,and discusses the relationship between putrescine and macrophage polarization in the process of gastric"inflammation and cancer transformation".Subsequent studies are expected to achieve the purpose of preventing or delaying the occurrence and development of gastric cancer by regulating putrescine metabolism and macrophage polarization.
关键词
胃癌/胃"炎癌转化"/巨噬细胞极化/腐胺/进展
Key words
Gastric cancer/Gastric"inflammatory cancer transformation"/Macrophage polarization/Putrescine/Progress
万方数据