Clinical outcomes between long-acting long protocol in follicular phase versus short-acting long protocol in luteal phase
Objective To compare the clinical outcomes of fresh transfer cycles of in vitro fertilization-embryo transfer(IVF-ET)between follicular phase long-acting long protocol and luteal phase short-acting long protocol.Methods The data of 313 patients taking IVF-ET(313 cycles)at Reproductive Medicine Center,Yantaishan Hospital from January 2018 to December 2022 were retrospectively analyzed.The cycles were divided into a folicular phase long-acting long protocol group(group A;141 cycles)and a luteal phase short-acting long protocol group(group B;172 cycles)according to the controlled ovarian stimulation protocols.Group A were(31.59±3.00)years old,with(3.48±2.38)years of infertility.Group B were(31.42±3.03)years old,with(3.38±2.38)years of infertility.The clinical outcomes were compared between the two groups by t and x2 tests.Results The total dosage of gonadotropin(Gn),Gn days,and endometrial thickness on the human chorionic gonadotropin(HCG)administration day in group A were more than those in group B[(29.53±11.18)ones vs.(23.83±7.03)ones,(9.61±1.80)d vs.(8.44±1.26)d,and(1.13±0.23)cm vs.(1.06±0.26)cm],with statistical differences(t=5.49,6.75,and 2.44;all P＜0.05).The levels of estrogen and luteinizing hormone(LH)on the HCG administration day,oocyte retrieved rate,and high-quality embryo rate in group A were lower than those in group B[(2 255.00±1 417.75)ng/L vs.(2 787.01±1 285.11)ng/L,(1.56±1.34)mIU/ml vs.(2.12±1.02)mIU/ml,81.00％(1 522/1 879)vs.84.74％(2 043/2 411),and 38.31％(344/898)vs.48.22％(597/1 238)],with statistical differences(t=3.44 and 4.14;x2=10.50 and 20.76;all P＜0.05).The clinical pregnancy rate and embryo implantation rate in group A were higher than those in group B[59.65％(68/114)vs.43.88％(43/98)and 44.39％(87/196)vs.31.82％(56/176)],with statistical differences(x2=5.26 and 6.19;all P＜0.05).Conclusion The clinical pregnancy rate and embryo implantation rate of fresh transfer cycles are higher by the follicular phase long-acting long protocol than by the luteal phase short-acting long protocol.
In vitro fertilization-embryo transferFolicular phase long-acting long protocolLuteal phase short-acting long protocolClinical pregnancy rateEmbryo implantation rate
万方数据
维普
