Effect of hysteroscopic endometrial resection on endometrial thickness and sex hormones in patients with abnormal uterine bleeding
Objective To explore the impact of hysteroscopic endometrial resection on endometrial thickness and sex hormones in patients with abnormal uterine bleeding.Methods One hundred and thirty patients with abnormal uterine bleeding treated at First Hospital,Northwest University from March 2020 to March 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 65 cases in each group.The control group were(41.18±4.00)years old;their disease course was(15.00±3.58)months.The observation group were(41.55±4.44)years old;their disease course was(14.38±3.82)months.The control group underwent traditional curettage surgery,and the observation group hysteroscopic endometrial electrosurgical resection.The surgical indicators,the endometrial thicknesses,menstrual volumes,and sex hormone levels before and 6 months after the surgery,and the incidences of adverse reactions were compared between the two groups by x2 and t tests.Results The time to first flatus,time to off bed activity,and hospital stay in the observation group were shorter than those in the control group[(4.35±0.85)h vs.(7.43±1.82)h,(8.73±1.52)h vs.(28.93±3.45)h,and(4.15±1.15)d vs.(7.43±1.96)d],with statistical differences between the two groups(t=12.362,43.198,and 11.637;all P＜0.001).Before the treatment,there were no statistical differences in endometrial thickness,menstrual volume,and sex hormone levels between the two groups(all P＞0.05).Six months after the treatment,endometrial thickness,menstrual volume,and levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),and estradiol(E2)in the observation group were better than those in the control group[(6.63±1.33)mm vs.(7.65±1.35)mm,(91.20±6.83)ml vs.(101.45±9.82)ml,(9.28±2.45)IU/L vs.(17.89±3.35)IU/L,(6.30±1.40)IU/L vs.(16.09±4.16)IU/L,and(69.03±6.13)pmol/L vs.(59.30±5.85)pmol/L],with statistical differences(t=4.339,6.909,16.726,17.982,and 9.258;all P＜0.009).The incidence of adverse reactions in the observation group was lower than that in the control group[3.08％(2/65)vs.16.92％(11/65)],with a statistical difference(t=6.923;P=0.009).Conclusion Hysteroscopic endometrial resection for patients with abnormal uterine bleeding can effectively reduce their endometrial thickness and menstrual volume and adverse reactions,and does not affect their sex hormone levels,so it is a safe and effective treatment option.
万方数据
维普
