Effect of Jintiange capsules and alfacalcitol for elderly patients with OVCF after PKP
Objective To investigate the effect of Jintiange capsules combined with alfacalcitol for elderly patients with osteoporotic vertebral compression fracture(OVCF)after percutaneous kyphoplasty of vertebral body(PKP).Methods Ninety-eight elderly patients with OVCF treated at Shandong Wendeng Osteopaths Yantai Hospital from February 2020 to May 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the coin toss method,with 49 cases in each group.The control group included 26 males and 23 females,with an age of(72.63±2.54)years;their disease course was(5.56±1.31)years.In the observation group,there were 29 males and 20 females;they were(72.89±2.60)years old;their disease course was(5.37±1.23)years.The patients in both groups took PKP;after PKP,the control group took alfacalcitol,and the observation group took alfacalcitol and Jintiange capsules,for 3 months.After the treatment,the treatment effects,symptom scores of traditional Chinese medicine,pain degrees,bone metabolism indicators,and adverse reactions were compared between the two groups.x2 and t tests were applied.Results The effective rate of the observation group was higher than that of the control group[97.96％(48/49)vs.(81.63％(40/49);x2=7.127;P=0.008].After 3 months'treatment,the scores of main symptoms,secondary symptoms,and pain degree in the in the observation group were lower than those in the control group[(3.20±0.28)vs.(4.58±0.30),(1.20±0.16)vs.(1.96±0.21),and(1.58±0.27)vs.(3.29±0.41);t=23.540,20.151,and 24.383;all P＜0.001].After 3 months'treatment,the levels of osteocalcin(BGP)and bone alkaline phosphatase(BALP)in the observation group were higher than those in the control group[(10.26±1.57)μg/L vs.(8.26±1.02)μg/L and(18.26±1.63)μg/L vs.(16.84±1.29)μg/L;t=7.478 and 4.782;both P＜0.001].The incidence of adverse reactions in the observation group was lower than that in the control group[6.12％(3/49)vs.(10.20％(5/49)],with no statistical difference(x2=0.136;P=0.712).Conclusion Jintiange capsules combined with alfacalcitol for elderly patients with OVCF after PKP can significantly improve their clinical symptoms and bone metabolism and reduce their pain degree and scores of traditional Chinese medicine symptoms,and is safe,so it is worth being generalized.
Osteoporotic vertebral compression fractureJintiange capsulesAlfacalcitolPercutaneous kyphoplasty of vertebral body
万方数据
维普
