Mesomeric effect of depression and loneliness on post-traumatic stress disorder and disability in patients with acute cerebral infarction
Objective To explore the mesomeric effect of affective disorders(depression and loneliness)on post-traumatic stress disorder(PTSD)and disability in patients with acute cerebral infarction.Methods Three hundred and twenty patients with acute cerebral infarction who were treated in Department of General Medicine,Xuzhou First People's Hospital between January 2020 and December 2022 were selected for the cross sectional study,including 273 males and 47 females.They were 46-85(64.8±15.9)years old.The data were collected from the patients using questionnaires,including general information,World Health Organization Disability Assessment Scale(WHO DAS 2.0),Post-Traumatic Stress Disorder Self-rating Scale(PTSD-SS),Self-rating Depression Scale(SDS),and University of California Los Angeles Loneliness Scale(UCLA).t and x2 tests were applied.Results The scores of WHO-DAS 2.0,PTSD-SS,SDS,and UCLA were(98.62±32.25),(83.15±24.01),(62.46±23.52),and(48.59±19.27)in the patients.Depression,loneliness,PTSD,and disability were correlated each other(all P＜0.05).The mediation model validation showed indirect effects of depression and loneliness on disability,with effect values of 0.196 and 0.110 and effect sizes of 14.75％and 20.48％.There was a chain mediation effect of the PTSD-loneliness-depression-disability,with the effect value of 0.061 and the effect size of 46.37％.PTSD did not show any significant direct effect on disability,with an effect value of PTSD and disability of 0.079.Conclusion Patients with acute cerebral infarction have PTSD psychological state,but PTSD does not directly affect disability,and it exerts its influence on disability through depression and loneliness by the pathway of mediated effects,and improve the patients'life quality.
万方数据
维普
