Value of serum sTREM-1 and sCD163 in evaluation of postoperative urinary infection in patients with benign prostatic hyperplasia
Objective To explore the value of serum levels of soluble myeloid trigger receptor 1(sTREM-1)and soluble hemoglobin sCD163(sCD163)in the evaluation of postoperative urinaryinfectioninpatientswithbenignprostatichyperplasia(BHP).Methods Atotalof 102 patients with BHP who underwent transurethral resection of prostate in Yan'an Hospital of Traditional Chinese Medicine from July 2020 to July 2023 were selected,and divided into an infected group(23 cases)and uninfected group(79 cases)according to whether they had postoperative urinary infection.The serum levels of sTREM-1 and sCD163 were compared between the two groups 7 days after the operation.The value of serum sTREM-1 and sCD163 in the evaluation of postoperative urinary infection in the patients was analyzed.The influencing factors of postoperative urinary infection in the patients were explored by the univariate analysis and multivariate logistic regression analysis.t and x2 tests were applied.Results The levels of sTREM-1 and sCD163 in the infected group were higher than those in the uninfected group[(76.47±8.29)ng/L vs.(52.65±6.91)ng/L and(71.25±6.64)μg/L vs.(49.26±5.37)μg/L],with statistical differences(t=13.893 and 16.358;both P＜0.05).The areas under the curves(AUC)of sTREM-1,sCD163,and the combination of the two for postoperative urinary infection in the patients were 0.734(95％CI 0.684-0.779),0.842(95％CI 0.798～0.887),and 0.904(95％CI 0.854-0.956),respectively.There were no statistical differences in age,body mass index,complication with hypertension,complication with diabetes mellitus,smoking history,drinking history,uric acid,triacylglycerol,and total cholesterol between the two groups(P＞0.05).The operation time,postoperative hospitalization time,and catheter indwelling time in the infected group were longer than those in the uninfected group[(73.21±6.14)min vs.(69.39±6.93)min,(7.29±1.29)d vs.(6.46±1.67)d,and(4.24±0.92)d vs.(3.75±0.84)d],and the levels of procalcitonin(PCT)and C-reactive protein(CRP)in the infected group were higher than those in the uninfected group[(2.37±0.45)μg/L vs.(1.43±0.57)μg/L and(36.06±6.54)mg/L vs.(26.23±5.34)mg/L],with statistical differences(t=2.384,2.197,2.410,7.268,and 7.374;all P＜0.05).The results of logistic regression analysis showed that PCT(OR=2.088,95％CI 1.436-3.035),CRP(OR=2.309,95％CI 1.536-3.472),serum sTREM-1(OR=3.047,95％CI 1.859-4.992),and serum sCD163(OR=2.617,95％CI 1.690-4.051)were risk factors for postoperative urinary infection in the patients(P＜0.05).Conclusion Serum sTREM-1 and sCD163 are highly expressed in patients with postoperative urinary infection after BPH surgery,and are risk factors for postoperative urinary infection.The combined detection of STREM-1 and SCD163 is of higher value in the evaluation of postoperative urinary infection.
万方数据
维普
