Light chain deposition disease(LCDD)is the most common form of monoclonal immunoglobulin deposition disease,in which plasma cells or B-lymphocytes secrete excessive amounts of monoclonal immunoglobulin light chains,which are deposited in tissues and cause organ dysfunction.LCDD is a systemic disease with multiple organ involvement,mainly in the kidney.Renal involvement is common in almost all patients with LCDD,while extra-renal involvement is less common,with cardiac,hepatic,gastrointestinal,peripheral,and autonomic nerve involvement being more common,and pulmonary involvement being very rare.Most of the organ impairment in LCDD is progressive,and spontaneous remission is rare.Extra-renal light chain deposition has clear independent effect on the patients'survival and prognosis.
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