国际医药卫生导报2024,Vol.30Issue(10) :1585-1589.DOI:10.3760/cma.j.issn.1007-1245.2024.10.001

阻塞性睡眠呼吸暂停低通气综合征与肠道菌群关系的研究进展

Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and gut microflora

卢曼路 朱继伟 丁红红 于燕 潘磊
国际医药卫生导报2024,Vol.30Issue(10) :1585-1589.DOI:10.3760/cma.j.issn.1007-1245.2024.10.001

阻塞性睡眠呼吸暂停低通气综合征与肠道菌群关系的研究进展

Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and gut microflora

卢曼路 1朱继伟 1丁红红 1于燕 1潘磊1
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作者信息

  • 1. 滨州医学院附属医院呼吸与危重症医学科,滨州 256603
  • 折叠

摘要

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种在睡眠时发生间歇性缺氧和复氧损伤的呼吸疾病.OSAHS与肠道菌群密切相关,可诱发肠道菌群紊乱、肠道代谢产物改变、肠道屏障受损和全身炎症反应;反过来,肠道菌群紊乱又可促进OSAHS进展,然而相关机制尚未完全阐明.本文就OSAHS与肠道菌群的相关研究进展进行综述.

Abstract

Obstructive sleep apnea hypopnea syndrome(OSAHS)is a respiratory disorder characterized by intermittent hypoxia and impaired reoxygenation that manifests during sleep.Researches have demonstrated a significant association between OSAHS and gut well-being,as it has the potential to disrupt the gut microbiome,modify the gut metabolites,compromise the integrity of the intestinal barrier,and trigger the systemic inflammation.This article provides a comprehensive review of the current research advancements pertaining to the relationship between OSAHS and gut microflora,and highlighting the potential role of disturbances in gut microflora in the progression of OSAHS,albeit with an incomplete understanding of the underlying mechanisms.

关键词

阻塞性睡眠呼吸暂停/低通气/肠道菌群/进展

Key words

Obstructive sleep apnea/Hypopnea/Gut microflora/Progress

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基金项目

山东省自然科学基金面上项目(ZR2021MH360)

滨州市农社领域科技创新政策引导计划(2023SHFZ033)

出版年

2024
国际医药卫生导报
中华医学会,国际医药卫生导报社

国际医药卫生导报

影响因子:0.781
ISSN:1007-1245
参考文献量48
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