Research progress of perivascular adipose tissue inflammation involved in the occurrence and development of aortic dissection
Aortic dissection(AD),also referred to as aortic dissection aneurysm,is a perilous condition associated with high mortality rate.Recent studies investigating the alterations in inflammatory markers during the disease progression suggest that inflammation plays a crucial role in determining the clinical outcomes of AD.The initial manifestation of inflammatory response occurs within the aortic adventitia and surrounding adipose tissue.Perivascular adipose tissue(PVAT)orchestrates arterial wall inflammation through proinflammatory mechanisms,which are closely linked to the occurrence and progression of various cardiovascular diseases.Consequently,detecting and intervening in PVAT inflammation holds immense significance for comprehending early pathophysiological changes in AD and implementing timely preventive measures among individuals at high risk.
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