Clinical value of miR-16-5p combined with plasma ZO-1 detection in prognostic prediction of infectious shock
Objective To explore the clinical value of miR-16-5p combined with plasma zonula occludens-1(ZO-1)detection in predicting the prognosis in patients with infectious shock.Methods A total of 137 patients with infectious shock admitted to Xi'an Union Hospital from January 2021 to August 2023 were retrospectively analyzed.There were 77 males and 60 females,aged 40 to 80 years.The levels of miR-16-5p and ZO-1 were detected.According to the 28-day survival,the patients were divided into a poor prognosis group(53 cases)and a good prognosis group(84 cases).Binary logistic regression analysis was used to analyze the risk factors affecting the patients'prognosis,and the receiver operating characteristic curve(ROC)was used to analyze the predictive value of miR-16-5p and ZO-1 for the patients'prognosis.x2 test and independent sample t test were used.Results Univariate analysis showed that the proportion of age ≥60 years old,C-reactive protein(CRP),procalcitonin(PCT),Sequential Organ Failure Assessment(SOFA)score,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,and miR-16-5p and ZO-1 levels in the poor prognosis group were higher than those in the good prognosis group(all P＜0.05).Binary logistic regression analysis showed that PCT(OR=1.783,95％CI:1.124-2.826),APACHE Ⅱ score(OR=3.011,95％CI:1.293-7.007),miR-16-5p(OR=4.628,95％CI:2.223-9.632),and ZO-1(OR=4.287,95％CI:1.915-9.594)were independent risk factors for poor prognosis in patients with infectious shock(all P＜0.05).ROC analysis results showed that the sensitivities of miR-16-5p,ZO-1,and their combination in predicting poor prognosis of infectious shock patients were 75.50％,71.70％,and 92.50％,the specificities were 72.60％,70.20％,and 89.30％,and the areas under the curves(AUC)were 0.805,0.810,and 0.921(all P＜0.05).Conclusion miR-16-5p and ZO-1 are independent risk factors for poor prognosis in patients with infectious shock,and clinical combined detection of miR-16-5p and ZO-1 levels can better predict the patients'prognosis.
Infectious shockPrognosisPlasma zonula occludens-1miR-16-5pPredictive value
万方数据
维普
