Effects of invasive-noninvasive sequential mechanical ventilation on blood gas analysis and inflammatory response in patients with severe pneumonia
Objective To investigate the effects of invasive-noninvasive sequential mechanical ventilation on blood gas analysis and inflammatory response in patients with severe pneumonia.Methods A total of 96 patients with severe pneumonia admitted to Air Force 986 Hospital from March 2020 to March 2023 were prospectively selected and were divided into a control group and an observation group by the random number table method,with 48 cases in each group.The control group was treated with invasive mechanical ventilation,including 25 males and 23 females,aged(55.36±5.21)years,with a body mass index(BMI)of(23.64±1.51)kg/m2.The observation group was treated with invasive-noninvasive sequential mechanical ventilation,26 males and 22 females,aged(55.42±5.25)years,with a BMI of(23.61±1.48)kg/m2.The surgery-related indicators,blood gas analysis indicators,lung function,and inflammatory response were compared between the two groups.Statistical methods used were t test and x2 test.Results Before treatment,there were no statistically significant differences between the observation group and the control group in terms of blood gas analysis,lung function,or inflammatory response(all P＞0.05).The duration of oxygen therapy[(12.32±2.21)d],invasive ventilation time[(5.22±1.03)d],and hospital stay[(18.31±2.76)d]in the observation group were shorter than those in the control group[(20.33± 3.25)d,(13.49±2.68)d,and(25.46±3.87)d],with statistically significant differences(t=14.120,19.956,and 10.421,all P＜0.001).After 2 weeks of treatment,the partial pressure of arterial blood oxygen and saturation of arterial blood oxygen in the observation group were higher than those in the control group[(78.02±6.01)mmHg(1 mmHg=0.133 kPa)vs.(71.25±5.86)mmHg,(93.72± 6.45)％vs.(89.52±6.33)％],but the partial pressure of arterial blood carbon dioxide was lower than that in the control group[(43.55±4.42)mmHg vs.(48.89±4.68)mmHg],with statistically significant differences(t=5.588,3.220,and 5.747,all P＜0.001).The static lung compliance(Cst)in the observation group was higher than that in the control group[(71.66±6.35)kPa vs.(60.25±5.21)kPa],but the extra vascular lung water index(EVLWI)was lower than that in the control group[(5.39± 1.02)ml/kg vs.(8.57±1.54)ml/kg],with statistically significant differences(t=9.624 and 11.927,both P＜0.001).The levels of white blood cell count[(6.71±1.25)×109/L],C-reactive protein(CRP)[(41.55±4.32)mg/L],and procalcitonin(PCT)[(2.01±0.52)μg/L]in the observation group were lowerthan those in the control group[(9.58±1.87)×109/L,(54.59±6.69)mg/L,and(2.59±0.68)μg/L],with statistically significant differences(t=8.840,11.345,and 4.694,all P＜0.001).The total complication rate of the observation group was lower than that of the control group[4.17％(2/48)vs.18.75％(9/48)],with a statistically significant difference(x2=5.031,P=0.025).Conclusion The use of invasive-noninvasive sequential mechanical ventilation in the treatment of patients with severe pneumonia,compared to solely invasive mechanical ventilation,effectively shortens the duration of oxygen therapy and hospitalization,improves the blood gas analysis and lung function,and reduces the inflammatory response,indicating that this treatment method is more beneficial for patients'recovery.
Severe pneumoniaInvasive-noninvasive sequential mechanical ventilationBlood gas analysisInflammatory response
万方数据
维普
