Effect of Zigan Bushen Runmu Decoction combined with acupuncture and sodium hyaluronate eye drops in xerophthalmia
Objective To analyze the effect of Zigan Bushen Runmu Decoction combined with acupuncture and sodium hyaluronate eye drops in xerophthalmia.Methods A total of 120 patients with xerophthalmia admitted to Shaanxi Provincial Hospital of Chinese Medicine were enrolled between May 2020 and May 2023.According to the random number table method,they were divided into a control group(60 cases)and a combination group(60 cases).In the control group,there were 32 males and 28 females,aged(42.58±3.15)years,and the course of disease was(4.21±1.13)months.In the combination group,there were 34 males and 26 females,aged(43.46± 3.27)years,and the course of disease was(4.09±1.09)months.The control group was treated with sodium hyaluronate eye drops,and the combination group was treated with Zigan Bushen Runmu Decoction and acupuncture on the basis of the control group for 2 weeks.The clinical curative effect and incidence of adverse reactions during treatment were compared between the two groups.The ocular symptom score,TCM syndrome score,tear film breakup time(BUT),Schirmer's I Test(SIT),and corneal fluorescein staining(FL)score were compared before and after treatment.t test and x2 test were used.Results The total clinical response rate of the combination group was higher than that of the control group[93.33％(56/60)vs.80.00％(48/60)],with a statistically significant difference(x2=4.615,P=0.032).After 2 weeks of treatment,the scores of ocular symptoms(eye drying,foreign body sensation,and fatigue)and TCM syndromes(dry mouth,dizziness and tinnitus,soreness and weakness of waist and knees,and insomnia and dreaminess)in the combination group were lower than those in the control group(t=15.123,8.527,10.752,14.267,6.734,16.780,and 8.226,all P＜0.001).After treatment,the BUT of the combination group was longer than that of the control group[(11.17±1.12)s vs.(7.74±0.73)s],the SIT was higher than that of the control group[(13.71±1.38)mm vs.(9.55±1.07)mm],and the FL score was lower than that of the control group[(4.07±0.42)points vs.(4.68±0.51)points],with statistically significant differences(t=19.873,18.453,and 7.152,all P＜0.001).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(x2=1.878,P=0.171).Conclusion The clinical effect of Zigan Bushen Runmu decoction combined with acupuncture and sodium hyaluronate eye drops is better than that of sodium hyaluronate eye drops,which can significantly improve the clinical eye symptoms,reduce the TCM syndrome scores,improve the tear film stability,and does not increase the incidence of clinical adverse reactions.
XerophthalmiaZigan Bushen Runmu DecoctionAcupunctureSodium hyaluronate eye dropsTear film stability
万方数据
维普
