Analysis of the clinical efficacy of budesonide combined with reduced glutathione in the treatment of acute exacerbation of chronic obstructive pulmonary disease in the elderly
Objective To analyze the clinical efficacy of budesonide combined with reduced glutathione in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in the elderly.Methods The clinical data of 85 elderly patients with AECOPD treated in the First Hospital of Yulin from May 2021 to December 2023 were retrospectively analyzed,who were divided into an observation group(42 cases)and a control group(43 cases)according to different treatment methods.In the control group,there were 22 males and 21 females,aged(72.13± 4.51)years,and the duration of chronic obstructive pulmonary disease(COPD)was(6.78±1.94)years.In the observation group,there were 28 males and 14 females,aged(73.56±4.97)years,and the duration of COPD was(6.22±1.35)years.The control group was treated with intravenous drip with reduced glutathione(1.5 g),once a day;on the basis of the control group,the observation group was treated with budesonide aerosol inhalation,1-2 in halations each time,twice a day.Both groups were treated for 14 d.The lung function,clinical efficacy,oxidative stress indexes,blood gas analysis indexes,serological indexes,and adverse reactions were compared between the two groups.x2 test and t test were used.Results The total effective rate of the observation group was higher than that of the control group[90.48％％(38/42)vs.72.09％(31/43)],with a statistically significant difference(x2=4.699,P=0.030).After 14 d of treatment,the levels of forced expiratory volume in the first second(FEV1),peak expiratory flow,FEV1/forced vital capacity(FVC),superoxide dismutase(SOD),and arterial blood oxygen partial pressure(PaO2)in both groups were increased(all P＜0.05),and those in the observation group were higher than those in the control group(all P＜0.05).The levels of malondialdehyde(MDA),arterial partial pressure of carbon dioxide(PaCO2),serum transforming growth factor-β(TGF-β),matrix metalloproteinase-9(MMP-9),and soluble myeloid cell trigger receptor-1(sTREM-1)in both groups were decreased(all P＜0.05),and those in the observation group were lower than those in the control group(all P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(x2=0.445,P=0.505).Conclusion In elderly patients with AECOPD,reduced glutathione combined with budesonide has a significant effect,which can improve the arterial blood gas,quality of life,and lung function,regulate the serum sTREM-1 expression,and reduce the oxidative stress and inflammation,with good safety.
万方数据
维普
