Effect of intravenous immunoglobulin combined with blue-purle light therapy on newborns with hemolytic jaundice
Objective To investigate the efficacy of intravenous immunoglobulin combined with blue-purle light therapy in the treatment of neonatal hemolytic jaundice and its effects on serum bilirubin level and cardiac and cerebral function.Methods A total of 78 newborns with hemolytic jaundice admitted to Xianyang Hospital of Yan'an University from August 2018 to March 2023 were prospectively selected and were divided into an observation group and a control group by the random number table method,with 39 newborns in each group.In the control group,21 boys and 18 girls,with a gestational age of(39.45±1.55)weeks,received blue-purle light therapy.In the observation group,22 boys and 17 girls,with a gestational age of(39.52±1.60)weeks,received intravenous immunoglobulin(1 g/kg)combined with blue-purle light therapy.Both groups were treated for 7 days until the total bilirubin dropped to a safe level.The clinical efficacy,serum bilirubin(total bilirubin,direct bilirubin,and indirect bilirubin)levels,levels of neurological and myocardial injury markers[S100 calcium-binding protein B(S100B),neuron-specific enolase(NSE),creatine kinase(CK),and creatine kinase isoenzyme(CK-MB)],Bilirubin-Induced Neurological Dysfunction(BIND)score,and Neonatal Behavioral Neurological Assessment(NBNA)score were compared between groups.t test and x2 test were used.Results After treatment,the total effective rate of the observation group was 94.87％(37/39),which was higher than that of the control group[79.48％(31/39)],with a statistically significant difference(x2=4.129,P=0.042).The levels of total bilirubin,direct bilirubin,indirect bilirubin,S100B,NSE,CK,and CK-MB in the observation group were lower than those in the control group,with statistically significant differences(all P＜0.05).The BIND score in the observation group was lower than that in the control group[(0.25±0.05)points vs.(0.38± 0.09)points],but the NBNA score was higher than that in the control group[(38.78±1.53)points vs.(37.12±1.17)points],with statistically significant differences(t=8.564 and 5.845,both P＜0.001).Conclusion Intravenous immunoglobulin combined with blue-purle light therapy is significantly effective in the treatment of neonatal hemolytic jaundice,capable of reducing the bilirubin level and protecting the cardiac function in infants.
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