Application of Jiawei Taohong Siwu Decoction combined with rivaroxaban in postoperative management of hip replacement surgery
Objective To investigate the application effect of Jiawei Taohong Siwu Decoction combined with rivaroxaban after hip replacement surgery,and to evaluate its impact on postoperative thrombosis prevention,inflammation factor level,and complications.Methods This study was a randomized controlled trial.A total of 120 patients undergoing hip replacement surgery in Baoji Hospital of Traditional Chinese Medicine from November 2019 to November 2023 were prospectively selected and were divided into an observation group(60 cases)and a control group(60 cases)by the random number table method.In the observation group,there were 30 males and 30 females,aged(65.25±10.33)years,and the course of disease was(4.72±1.15)years.In the control group,there were 28 males and 32 females,aged(63.96±10.87)years,and the course of disease was(4.68±1.13)years.The control group received rivaroxaban treatment,and the observation group was treated with a combination of Jiawei Taohong Siwu Decoction and rivaroxaban.The differences in coagulation function indexes[plasma prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB),and D-dimer(D-D)],hemorheological indexes(whole blood viscosity,plasma viscosity,hematocrit,erythrocyte rigidity index,and erythrocyte deformability index),pro-inflammatory cytokine[C-reactive protein(CRP)],complications,and deep vein thrombosis(DVT)were compared between the two groups before and 14 days after treatment.Independent sample t test,paired sample t test,and x2 test were used.Results Before treatment,there were no statistically significant differences in various indexes between the two groups(all P＞0.05).After 14 days of treatment,the PT[(15.79±2.33)s],TT[(19.05±3.12)s],and APTT[(30.21±4.07)s]in the observation group were all longer than those in the control group[(14.01±2.67)s,(15.52±2.79)s,and(27.33±3.49)s](all P＜0.05);the levels of FIB[(3.52±1.08)g/L]and D-D[(0.22±0.04)mg/L]in the observation group were lower than those in the control group[(4.09±1.06)g/L and(0.33±0.06)mg/L](both P＜0.05).After 14 days of treatment,the whole blood viscosity[(4.07±1.28)mPa·S],plasma viscosity[(1.48±0.43)mPa·S],hematocrit[(37.56±2.79)％],and erythrocyte rigidity index[(5.47±0.77)]in the observation group were lower than those in the control group[(4.65±0.27)mPa·S,(2.02±0.39)mPa·S,(42.06±2.17)％,and(6.23± 0.84)](all P＜0.05);the erythrocyte deformability index in the observation group was higher than that in the control group[(0.84±0.03)vs.(0.74±0.07)](P＜0.05).After 14 days of treatment,the CRP level in the observation group[(4.25±1.09)mg/L]was lower than that in the control group[(7.97± 2.14)mg/L](P＜0.05).Within 14 days after treatment,the total complication rate[13.33％(8/60)]and the positive rate of DVT[6.67％(4/60)]in the observation group were lower than those in the control group[25.00％(15/60)and 20.00％(12/60)](both P＜0.05).Conclusion The combined application of Jiawei Taohong Siwu Decoction and rivaroxaban significantly prevents DVT after hip or knee replacement surgery,effectively improves the hemorheological parameters,inhibits the blood coagulation,and reduces the incidence of complications.
Hip replacement surgeryRivaroxabanJiawei Taohong Siwu DecoctionDeep vein thrombosisTherapeutic efficacy
万方数据
维普
