Analysis of findings of DCE-MRI combined with high B-value DWI in ovarian cancer patients
Objective To investigate the findings of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI)combined with high B-value diffusion-weighted imaging(DWI)in patients with ovarian cancer.Methods Clinical data of 50 patients diagnosed with ovarian cancer(observation group)admitted to Xianyang Hospital,Yan'an University from June 2020 to June 2023 were retrospectively analyzed,and 50 healthy controls during the same period were selected as the control group.The control group was(33.58±5.47)years old;the observation group was(33.37± 5.53)years old,with 8 cases in stage Ⅰ,25 cases in stage Ⅱ,12 cases in stage Ⅲ,and 5 cases in stage Ⅳ according to the International Federation of Gynecology and Obstetrics(FIGO)stage.Both groups underwent DCE-MRI and high B-value DWI examination.The quantitative parameters of DCE-MRI,including volume transfer constant(Ktrans),rate constant(Kep),and extracellular volume fraction(Ve),were compared between the two groups.The apparent diffusion coefficient(ADC)of DWI was observed and compared between the two groups.The receiver operating characteristic curve(ROC)was plotted and the area under the curve(AUC)was calculated to evaluate the diagnostic efficacy of DCE-MRI combined with high B-value DWI in ovarian cancer patients.F test was used.Results The values of Ktrans,Kep,and Ve in the observation group were(0.43±0.05)min,(0.85±0.13)min,and(0.75±0.25),which were higher than those in the control group[(0.07± 0.06)min,(0.27±0.12)min,and(0.26±0.16)],and the ADC value of the observation group was(0.93±0.13)×10-3mm2/s,which was significantly lower than that of the control group[(1.53± 0.23)×10-3 mm2/s],with statistically significant differences(all P＜0.05).The values of Ktrans,Kep,and Ve ranked as follow:stage Ⅳ＞stage Ⅲ＞stage Ⅱ＞stage Ⅰ,and the ADC value ranked as follow:stage Ⅳ＜stage Ⅲ＜stage Ⅱ＜stage Ⅰ,with statistically significant differences(all P＜0.05).According to ROC analysis,the diagnostic sensitivity and specificity of DCE-MRI for different stages of ovarian cancer were 85.35％and 90.14％,the diagnostic sensitivity and specificity of high B-value DWI for different stages of ovarian cancer were 82.45％and 87.14％,and the diagnostic sensitivity and specificity of DCE-MRI combined with high B-value DWI for different stages of ovarian cancer were 94.14％and 95.85％.Conclusions DCE-MRI combined with high B-value DWI examination has higher efficacy in ovarian cancer patients,which is significantly superior to single detection.When B-value is 1 600 s·mm-2,combined DCE-MRI has higher sensitivity and specificity for clinical staging diagnosis of ovarian cancer.As an auxiliary means of clinical non-invasive diagnosis,the two examination methods can complement each other,avoiding misdiagnosis of ovarian cancer,have important clinical value for the patients'treatment and prognosis.
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