Construction of prognostic mode for patients with supraglottic laryngeal carcinoma undergoing surgery
Objective To construct and verify the prognostic mode for patients with supraglottic laryngeal carcinoma undergoing aperture low temperature plasma radiofrequency ablation.Methods One hundred and twenty-eight patients with supraglottic laryngeal carcinoma admitted to Weinan First Hospital from January 2018 to January 2021 were selected as the study objects,and were randomly divided into a training set(103 cases)and a validation set(25 cases)according to 8:2.There were 66 males and 37 females in the training set;they were(53.95±9.03)years old;there were 82 cases of stage Ⅱ and 21 cases of stage Ⅲ.There were 18 males and 7 females in the verification set;they were(54.86±8.69)years old;there were 20 cases of stageⅡ and 5 cases of stage Ⅲ.All the patients took aperture low temperature plasma radiofrequency ablation,and were followed up for 3 years after the surgery,and the recurrence was recorded.The factors influencing the patients'prognosis were analyzed,and a prognostic mode was established,validated,and evaluated.t and x2 test were used.The logistic regression model was used to analyze the influencing factors.Results Postoperative recurrence occurred in 21.36％(22/103)patients in the training set and in 20.00％(5/25)patients in the verification set.The logistic regression analysis showed that tumor stage(OR=5.171;95％CI 2.128-12.566),differentiation degree(OR=4.764;95％CI 1.960-11.577),and vascular endothelial growth factor(VEGF)level(OR=3.892;95％CI 1.602-9.459)were the patients'prognostic factors(all P＜0.05).The above influencing factors were used as predictive variables,and a nomogram prediction mode was established.The total score of each factor ranged from 83 to 278,and the corresponding risk rate ranged from 0.07 to 0.52.The results of the nomogram mode showed that the C-index was 0.801(95％CI 0.759-0.829),and the correction curve for predicting the patients'prognosis was close to the ideal curve(P＞0.05).The receiver operating characteristic curve(ROC)results of the training set showed that the sensitivity,specificity and AUC of the nomogram mode for predicting the patients'prognosis were 77.27％,83.95％,and 0.854(95％CI 0.772-0.935).The ROC results of the validation set showed that the sensitivity,specificity and AUC of the nomogram mode for predicting the patients'prognosis were 80.00％,85.00％,and 0.872(95％CI 0.793-0.945).Conclusions Tumor stage,differentiation degree,and VEGF level are closely related to the prognosis of patients with supraglottic laryngeal carcinoma undergoing aperture low-temperature plasma radiofrequency ablation.The prediction mode is effective in predicting the prognosis of patients with supraglottic laryngeal carcinoma undergoing aperture low-temperature plasma radiofrequency ablation.
Supraglottic laryngeal carcinomaCryoplasma radiofrequency ablation via aperturePrognosisNomogram model
万方数据
维普
