Effect of Yiqixue Buganshen Recipe on pregnancy outcomes of repeated implantation failure patients taking frozen thawed embryo transfer
Objective To investigate the effect of Yiqixue Buganshen Recipe(YBR)on the preghancy outcomes of repeated implantation failure(RIF)patients taking frozen-thawed embryo transfer(FET).Methods The clinical data of 120 patients with RIF who underwent FET in Department of Reproductive Health and Infertility,Guangzhou First People's Hospital from January 2017 to June 2023 were retrospectively analyzed.The patients were 25-35 years old and had regular menstruation.The 120 patients were divided into a control group and a study group according to whether they took YBR before FET,with 60 cases in each group.Fifty-seven patients who took FET and had no history of embryo transfer during the same period were set as a normal group.All the three groups used hormone replacement therapy(HRT)protocol for endometrium preparation.The study group took YBR for three menstrual cycles before endometrial preparation(the proliferation recipe after menstruation:it was cooked to 20 ml,and made into 10 g granules per packet;the patients took 1 packet per day in the morning and at night from the menstruation was clean until ovulation.Luteinizing hormone recipe:it was cooked to 20 ml and made into 10 g granules per packet;the patients took 1 packet per day in the morning and at night from the ovulation until day 1-3 of menstruation).The endometrial thicknesses,pulsatility indexes(PI),resistance indexes(RI),implantation rates(IR),and pregnancy rates(PR)were compared between the 3 groups.One-way ANOVA and x2 test were used.Results The endometrial thickness,PI,and RI were(10.33±2.27)mm,(1.86±0.52),and(0.56±0.10)in the normal group,were(10.24±1.81)mm,(1.96±0.21)and(0.58±0.90)in the study group,and were(9.03±1.41)mm,(1.97±0.20),and(0.62±0.09)in the control group,with statistical differences(F=8.40,6.08,and 6.89;all P＜0.05).The IR and PR in the normal group and the study group were higher than those in the control group[43.9％(43/98)vs.38.8％(40/103)vs.25.2％(26/103)and 57.9％(33/57)vs.55.0％(33/60)vs.35.0％(21/60);x2=8.18 and 7.37;both P＜0.05].Conclusion YBR can improve the pregnancy outcomes of RIF patients in FET cycles by reducing the uterine blood flow RI and PI,increasing endometrial thickness,and enhancing the embryo IR and clinical PR.
万方数据
维普
