Correlation of PD-L1 expression with clinical pathological characteristics and 18F-FDG PET/CT metabolic parameters in esophageal squamous cell carcinoma
Objective To explore the correlation of programmed death-ligand 1(PD-L1)expression with clinical pathological characteristics and 18F-FDG PET/CT metabolic parameters in esophageal squamous cell carcinoma.Methods The clinical pathological characteristics,and preoperative 18F-FDG PET/CT data of 91 patients with esophageal squamous cell carcinoma who underwent surgery in Jieyang People's Hospital from January 2019 to August 2022 were retrospectively analyzed.Among them,there were 66 males and 25 females,with a median age of 65.The PD-L1 expression was positive in 45 cases and negative in 46 cases.The correlation of PD-L1 expression level with gender,age,tumor location,tumor differentiation degree,neural bundle invasion,vascular cancer embolism,T stage,N stage,TNM stage,maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)of the primary lesion in esophageal squamous cell carcinoma were analyzed.The Mann-Whitney U nonparametric test,x2 test,Spearman correlation analysis,and receiver operating characteristic curve(ROC)were used.Results Positive PD-L1 expression was positively correlated with T stage,SUVmax,and TLG(r=0.215,0.297,and 0.264;all P＜0.05).The areas under the ROC's of SUVmax and TLG for predicting PD-L1 expression were 0.671 and 0.623,respectively.Conclusions PD-L1 expression is correlated with T staging and metabolic parameters SUVmax and TLG from 18F-FDG PET/CT in primary esophageal squamous cell carcinoma.These parameters can reflect the level of PD-L1 expression to some extent.
Esophageal squamous cell carcinomaPositron emission tomography18F-fluoro-2-deoxy-D-glucoseProgrammed cell death ligand-1
万方数据
维普
