Value of magnetic resonance imaging multimodal parameters combined with miR-21 and lncRNA FER1L4 in distinguishing hepatocellular carcinoma from focal nodular hyperplasia
Objective To explore the effectiveness and accuracy of magnetic resonance imaging(MRI)multimodal parameters combined with microRNA-21(miR-21)and long non-coding RNA(lncRNA)FER1L4 in differentiating hepatocellular carcinoma(HCC)from focal nodular hyperplasia(FNH).Methods Seventy-eight patients treated at Yulin First Hospital from January 2014 to December 2022 were selected as the study objects,including 50 cases of HCC and 28 cases of FNH.There were 29 males and 21 females in the HCC group;they were(59.03±13.12)years old,with a disease course of(2.12±1.43)years.There were 16 males and 12 females in the FNH group;they were(31.48±9.29)years old,with a disease course of(2.27±1.39)years.The MRI multimodal parameters[persistent enhancement,rapid in and out,signal intensity(Sl)enhancement ratio,standardized apparent diffusion coefficient(SIADC),peritumoral low signal halo,contrast filling defect,linear low signal separation,and central stellate scar]and levels of miR-21 and lncRNA FER1L4 in the lesion tissues were compared between the two groups.The diagnostic efficacies of MRI,miR-21,and lncRNA FER1L4 were assessed by the receiver operating characteristic curves(ROC).t and x2 tests were used.Results There were no statistical differences in the enhancement patterns and SIenhancement ratebetween the two groups(x2=3.640;t=0.207;both P＞0.05).However,the SIADC in the FNH group was higher than that in the HCC group(t=7.906;P＜0.05).There were statistical differences in the morphological features(peritumoral low signal halo,contrast filling defect,linear low signal separation,and central stellate scar)during the hepatobiliary phase between the two groups(x2=17.160,17.814,21.840,and 13.868;all P＜0.05).The miR-21 expression in the HCC tissue was higher than that in the FNH tissue,whereas the FER1L4 expression in the HCC tissue was lower than that in the FNH tissue(both P＜0.05).When combining MRI,miR-21,and lncRNA FER1L4,49 cases of HCC and 27 cases of FHN were correctly identified,with an area under the curve(AUC)of 0.972;the sensitivity and specificity were 98.0％and 96.4％,respectively,with a Youden index of 0.944.Conclusion The combination of MRI multimodal parameters with miR-21 and lncRNA FER1L4 levels in lesion tissues can effectively distinguish HCC from FNH.
Magnetic resonance imagingHepatocellular carcinomaFocal nodular hyperplasiaMiR-21FER1L4
万方数据
维普
