首页|复方金菊口服液指纹图谱探索性研究

复方金菊口服液指纹图谱探索性研究

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目的 本研究旨在通过高效液相色谱法(HPLC)建立复方金菊口服液的指纹图谱,为其质量控制和评价提供科学依据。方法 采用Discovery C18色谱柱(250 mm×4。6 mm,5 μm),流动相为乙腈-0。1%磷酸溶液梯度洗脱,流速为1。0 ml/min,柱温为30 ℃,检测波长245 nm。研究时间为2022年1月至2023年12月。结果 建立复方金菊口服液的指纹图谱,共标定21个共有峰,并指认其中6个共有峰。结论 HPLC简单、稳定,各峰分离良好,为复方金菊口服液的质量控制和评价提供科学依据。
Research on the fingerprint quality of compound Jinju oral liquid
Objective To provide some scientific references for controlling the quality and evaluation of compound Jinju oral liquid establishing the fingerprint of compound Jinju oral liquid by high performance liquid chromatography(HPLC).Methods The Discovery C18 chromatography column(250.0 mm×4.6 mm,5 μm)was used;the mobile phase was acetonitrile-0.1%phosphate solution gradient ution;the flow rate was 1.0 ml/min;the column temperature was 30 ℃;the detection wavelength was 245 nm.The study was from January 2022 to December 2023.Results A fingerprint of compound Jinju oral solution was established.A total of 21 common peaks were calibrated,and 6 of the common peaks were identified.Conclusion HPLC is simple and stable,and can provide some scientific references for controlling the quality and evaluation of compound Jinju oral liquid.

High performance liquid chromatographyCompound Jinju oral liquidFingerprint

刘宴林、阮丽英、谭本仁、刘学华、周秋霞、徐韵

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汕头大学医学院附属粤北人民医院药学部,韶关 512026

丽珠集团利民制药厂,韶关 512028

高效液相色谱法 复方金菊口服液 指纹图谱

2022年广东省中医药局中医药科研立项项目

20222228

2024

国际医药卫生导报
中华医学会,国际医药卫生导报社

国际医药卫生导报

影响因子:0.781
ISSN:1007-1245
年,卷(期):2024.30(11)