Effect of modified electric convulsive therapy combined with SSRIS on cognitive function in patients with severe depression
Objective To investigate the effect of modified electric convulsive therapy(MECT)combined with serotonin reuptake inhibitors(SSRI)on cognitive function in patients with severe depression.Methods A total of 50 patients with severe depression admitted to Guangdong Zhongnengjian Dianli Hospital from June 2022 to June 2023 were selected for the randomized controlled trial,and were divided into an experimental group and a control group by the random number table method,with 25 cases in each group.There were 14 males and 11 females in the experimental group;they were(35.32±3.66)years old;their disease course was(7.56±1.45)months.There were 10 males and 15 females in the control group;they were(34.98±3.09)years old;their disease course was(8.12±1.26)months.The experimental group took MECT 3 times a week for 4 weeks and SSRI sertraline 100-200 mg/d for 2 weeks,while the control group only took sertraline.The scores of Hamilton Depression Scale(HAMD-24),Wisconsin Card Sorting Test(WCST),Wechsler Adult Intelligence Scale(WAIS-RC),and Iowa Gambling Task(IGT)before the treatment and after 2 and 4 weeks'treatment were compared between the two groups by the independent-sample t test and x2 test.Results The scores of HAMD-24 after 2 and 4 weeks'treatment in the observation group were lower than those in the control group[(23.61±3.27)vs.(29.41±3.13)and(18.43±5.22)vs.(21.63±5.32)],with statistical differences between the two groups(both P＜0.05).After 4 weeks'treatment,the score of the number of completed classification in WSCT of the observation group was significantly higher than that of the control group[(6.13±2.01)vs.(5.21±1.72)],with no statistical difference between the two groups(P＞0.05).The total score and the scores of positive and negative sequences of WAIS-RC after 2 weeks'treatment in the observation group were lower than those in the control group[(10.51±3.50)vs.(13.67±4.13),(8.64±1.24)vs.(11.22±2.21),and(3.16±1.21)vs.(4.20±1.15);all P＜0.05].The total net scores after 2 and 4 weeks'treatment in the observation group were higher than those in the control group[(1.63±0.21)vs.(1.27±0.56)and(2.64±1.21)vs.(1.67±0.74);both P＜0.05].Conclusion MECT combined with SSRI for patients with severe depression is more effective than SSRI monotherapy,and can effectively improve their cognitive function,and has short-term effect on their working and memory function,but with the extension of time,their working and memory function will restore.
Severe depressionModified electric convulsive therapySerotonin reuptake inhibitorsCognitive function
万方数据
维普
