Correlation of ST6Gal]with clinicopathological features and prognosis of patients with colorectal cancer
Objective To study the relationship between β-galactoside α-2,6-sialyltransferase 1(ST6Gal1)and the clinicopathological characteristics and prognosis of patients colorectal cancer(CRC).Methods A total of 102 patients with CRC who underwent surgical resection and had tumor and adjacent tissues preserved in Department of Pathology,Shaanxi Nuclear Industry 215 Hospital from December 2018 to June 2023 were selected.The positive rates of ST6Gal1 in the tumor tissues of the patients with different clinicopathological characteristics were compared.The patients were followed up,and their prognosis was recorded.The survival patients were set as a survival group,and the dead patients a death group.There were 37 males and 25 females in the survival group;there were 48 patients who were ≥60 years old and 25 patients who were＜60 years old.In the death group,there were 15 males and 16 females;there were 25 cases who were ≥60 years old and 6 cases who were＜60 years old.The prognostic factors of the patients with CRC were analyzed by the COX regression model.Kaplan-Meier curves were plotted to compare the prognosis of the patients with positive and negative expression of ST6Gal1,and Log-rank test was performed.Results The positive rate of ST6Gal1 in the CRC tissue was higher than that in the paracancer tissue[67.62％(79/102)vs.13.33％(12/102);x2=58.417,P＜0.001].Compared with those in the patients with CRC TNM stage Ⅰ-Ⅱ[50.00％(17/34)],adenocarcinoma[71.79％(56/78)],highly differentiated CRC[69.84％(44/63)],no serous infiltration[60.00％(21/35)],and no lymph node metastasis[62.50％(30/48)],the positive rates of ST6Gal1 were higher in the patients with TNM stage Ⅲ-Ⅳ[91.18％(62/68)],mucinous adenocarcinoma/sig-ring cell carcinoma[95.83％(23/24)],serous infiltration[86.57％(58/67)],medium/low differentiation[89.74％(35/39)],and lymph node metastasis[90.74％(49/54)](x2=22.006,6.072,5.463,9.291,and 11.605;P＜0.001,=0.014,=0.019,=0.002,and=0.001).The COX regression model showed that TNM stage Ⅲ-Ⅳ,serosal invasion,tumor diameter ≥5 cm,moderate/low differentiation,lymph node metastasis,and ST6Gal1 positivity were risk factors for poor prognosis of the patients with CRC(all P＜0.05).Log-rank test showed that there was a statistical difference in the Kaplan-Meier curves between the patients with positive and negative expressions of ST6Gal1(x2=8.578;P=0.003).Conclusion ST6Gal1 is abnormally highly expressed in CRC tissue,is related to various clinicopathological characteristics,and is one of the risk factors for poor prognosis of patients with CRC.
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