For malignant solid tumors,we use surgery,radiotherapy,chemotherapy,and other treatments to improve the patients'survival rate,but the application of chemotherapy drugs has the disadvantages of low selectivity and toxicity and side effects.Through research,the efficacy of targeted drugs has shown good prospects.Claudin18.2 is a unique molecule for different malignant solid tumors,and targeted therapy for Claudin18.2 is the most promising research hotspot.This study reviews the research progress of Claudin18.2.