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规范随访监控机制对高危儿生长发育的影响

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目的 通过建立高危儿规范随访监控机制,分析对高危儿生长发育的影响,为制定合理的营养支持和早期干预策略提供依据。方法 选取2021年1月至2023年1月滨州市中心医院收治住院的高危儿260例,依据高危儿是否定期返院进行随访分为规范随访组和非规范随访组。规范随访组170例高危儿中男78例,女92例,日龄12(7,14)d,高危因素1项112例、2项58例;非规范随访组90例高危儿中男41例,女49例,日龄13(7,15)d,高危因素1项59例、2项31例。规范随访组是指根据出院随访计划表在出院后定期返院随访,并根据返院的各项检查结果,及时评估并给予干预措施;非规范随访组为出院后未规律返院随访且失访次数>3次,但有2周龄、3月龄、6月龄、12月龄4个时间点的发育评估资料。比较两组高危儿6月龄、12月龄的体格发育情况,2周龄、4周龄时的新生儿神经行为测定(NBNA)评分,3月龄、1月龄的Gesell发育量表评估情况及并发症发生情况。采用t检验、x2检验、U检验。结果 规范随访组高危儿6月龄的身长、体质量和头围分别为(70。4±7。8)cm、(8。7±1。6)kg、(43。4±1。5)cm,12 月龄分别为(78。3±6。4)cm、(11。4±1。5)kg、(45。3±1。5)cm,均高于非规范随访组的(62。8±8。7)cm、(7。6±2。3)kg、(41。4±1。1)cm、(76。6±7。6)cm、(10。7±1。9)kg、(44。8±1。6)cm,差异均有统计学意义(t=7。178、P<0。001,t=4。509、P<0。001,t=12。830、P<0。00 1,t=1。907、P=0。058,t=3。256、P=0。001,t=2。498、P=0。013)。规范随访组高危儿出生2周、4周时NBNA评分分别为(36。67±2。18)分、(38。59±1。61)分,非规范随访组分别为(36。62±2。21)分、(37。73±1。34)分,两组出生4周时NBNA评分均比出生2周时升高,且规范随访组高于非规范随访组,差异均有统计学意义(均P<0。05)。3月龄时,两组高危儿的大运动、精细动作、适应性行为、语言、个人社交发育迟缓率比较,差异均无统计学意义(均P>0。05);12月龄时,两组高危儿的智能发育迟缓率均明显降低,且非规范随访组高危儿的智能发育迟缓率均高于规范随访组,差异均有统计学意义(均P<0。05)。规范随访组高危儿营养不良、贫血的总发生率低于非规范随访组[5。8%(10/170)比25。4%(23/90)],差异有统计学意义(x2=20。553,P<0。001)。结论 建立规范的随访监控机制,连续性管理高危儿的生长发育,可及时发现偏离并给予早期干预,可促进高危儿的体格发育及神经心理行为发育,在高危儿生长发育过程中有重要临床意义。
Effect of standardized follow-up monitoring mechanism on the growth and development of high-risk infants
Objective By establishing the standardized follow-up monitoring mechanism for high-risk infants,the influence on the growth and development of high-risk infants was analyzed,and the basis for formulating reasonable nutrition support and early intervention strategies was provided.Methods From January 2021 to January 2023,260 high-risk infants were hospitalized in Binzhou Central Hospital.According to whether the high-risk infants returned to hospital regularly for follow-up,they were divided into a standardized follow-up group and a non-standardized follow-up group.In the standardized follow-up group,there were 170 high-risk infants,78 boys and 92 girls,aged 12(7,14)days,112 cases with 1 high-risk factor and 58 cases with 2 high-risk factors.In the non-standardized follow-up group,there were 90 high-risk infants,41 boys and 49 girls,aged 13(7,15)days,59 cases with 1 high-risk factor and 31 cases with 2 high-risk factors.The standardized follow-up group referred to regular return to the hospital after discharge according to the discharge follow-up schedule,and timely assessment and intervention measures were given according to the results of various examinations.In the non-standardized follow-up group,the infants did not return to the hospital regularly after discharge for follow-up and the number of lost visits was>3 times,but there were developmental assessment data at 4 time points of 2 weeks,3 months,6 months,and 12 months old.The physical development of high-risk infants at 6 months and 12 months old were compared between the two groups.The Neonatal Behavioral Neurological Assessment(NBNA)scores at 2 weeks and 4 weeks old were compared between the two groups.The Gesell development scale of 3-month old and 12-month old of high-risk infants were compared.The incidences of complications were compared between the two groups.t test,x2 test,and U test were used.Results The body length,body weight,and head circumference of the high-risk infants in the standardized follow-up group were(70.4±7.8)cm,(8.7±1.6)kg,and(43.4±1.5)cm at 6 months old,and(78.3±6.4)cm,(11.4±1.5)kg,and(45.3±1.5)cm at 12 months old,respectively,which were higher than(62.8±8.7)cm,(7.6±2.3)kg,(41.4±1.1)cm,(76.6±7.6)cm,(10.7±1.9)kg,and(44.8±1.6)cm in the non-standardized follow-up group,with statistically significant differences(t=7.178,P<0.001;t=4.509,P<0.001;t=12.830,P<0.001;t=1.907,P=0.058;t=3.256,P=0.001;t=2.498,P=0.013).The NBNA scores of the high-risk infants in the standardized follow-up group were(36.67±2.18)and(38.59±1.61)points at 2 weeks and 4 weeks old,respectively,and those in the non-standardized follow-up group were(36.62±2.21)and(37.73±1.34)points,respectively.The NBNA scores of the two groups at 4 weeks old were higher than those at 2 weeks old,and the NBNA score of the standardized follow-up group at 4 weeks old was higher than that of the non-standardized follow-up group,with statistically significant differences(all P<0.05).At 3 months old,there were no statistically significant differences in the developmental retardation rates of gross motor,fine motor,adaptive behavior,language,or personal social between the two groups(all P>0.05).At 12 months old,the developmental retardation rates of the high-risk infants in both groups were significantly decreased,and the retardation rates of the high-risk infants in the non-standardized follow-up group were higher than those in the standardized follow-up group,with statistically significant differences(all P<0.05).The overall incidence of malnutrition and anemia in the standardized follow-up group was lower than that in the non-standardized follow-up group[5.8%(10/170)vs.25.4%(23/90)],with a statistically significant difference(x2=20.553,P<0.001).Conclusion The establishment of standardized follow-up monitoring mechanism,sequential management of the growth and development of high-risk infants,and timely early intervention can promote their physical and neuropsychological development,which has important clinical significance in the growth and development of high-risk infants.

High-risk infantsFollow-upStandardPhysical developmentNeuropsychological development

王丽、李晨、吕攀攀、崔传英

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滨州市中心医院儿童保健科,滨州 251700

滨州市中心医院检验科,滨州 251700

滨州医学院附属医院儿童保健科,滨州 256600

高危儿 随访 规范 体格发育 神经心理发育

山东省医药卫生科技发展计划滨州市科技发展计划

2020060406942014ZC0155

2024

国际医药卫生导报
中华医学会,国际医药卫生导报社

国际医药卫生导报

影响因子:0.781
ISSN:1007-1245
年,卷(期):2024.30(12)