Clinical significance of DWI scanning combined with conventional MRI sequence examination in the diagnosis of neonatal hypoxic-ischemic encephalopathy
Objective To explore the clinical significance of diffusion-weighted imaging(DWI)scanning combined with conventional magnetic resonance imaging(MRI)sequence examination in the diagnosis of neonatal hypoxic-ischemic encephalopathy(HIE).Methods A total of 85 newborns with HIE who visited the Affiliated Hospital of Northwest University,Xi'an No.3 Hospital,from January 2020 to October 2023 were selected as the HIE group,and 85 healthy newborns were selected as the control group during the same period.There were 48 boys and 37 girls in the HIE group,with gestational age of 38-40(39.23±0.65)weeks and birth weight of 2.21-4.13(3.24±0.41)kg.There were 43 boys and 42 girls in the control group,with gestational age of 37-41(39.03±0.84)weeks and birth weight of 2.19-4.06(3.11±0.45)kg.The results of DWI scanning combined with conventional MRI sequence examination in the HIE group were analyzed,and the DWI parameters[the values of apparent diffusion coefficient(ADC)of brain tissue in the thalamus,centrum ovale majus,parietal white matter,lenticular nucleus,and posterior limb of the internal capsule]of the two groups were compared.The results of lesion detection in each sequence of conventional MRI were analyzed.The diagnostic efficacy of DWI scanning,conventional MRI sequence alone and in combination were compared.Independent sample t test and x2 test were used.Results The ADC values of brain tissue in the thalamus[(0.84±0.05)mm2/s],centrum ovale majus[(1.04±0.12)mm2/s],parietal white matter[(1.14±0.04)mm2/s],lenticular nucleus[(0.76±0.04)mm2/s],and posterior limb of the internal capsule[(0.73±0.03)mm2/s]in the HIE group were lower than those in the control group[(1.16±0.08)mm2/s,(1.83±0.17)mm2/s,(1.68±0.16)mm2/s,(1.23±0.09)mm2/s,and(1.26±0.10)mm2/s](all P＜0.05).The diagnostic sensitivity of DWI scanning combined with conventional MRI sequence examination was 97.65％(83/85),which was higher than those of DWI scanning and conventional MRI sequence examination alone,and the missed diagnosis rate was 2.35％(2/85),which was lower than those of DWI scanning and conventional MRI sequence examination alone(all P＜0.05).Conclusion The combination of DWI scanning and conventional MRI sequence examination has a high sensitivity in the diagnosis of neonatal HIE and a low missed diagnosis rate,which can provide reliable basis for clinical diagnosis of HIE.
万方数据
维普
