Meta-analysis of on efficacy and safety of acupuncture combined with Huoxue Quyu prescription in treatment of migraine
Objective To evaluate the clinical efficacy,adverse reactions,and potential mechanism of acupuncture combined with Huoxue Quyu prescription in the treatment of migraine.Methods The China Biomedical Literature Database,CNKI,Wanfang Digital Journal Database,VIP Database,PubMed,and Cochrane Library were searched to collect clinical randomized controlled trials(RCTs)from their establishment to April 10,2023.The control group were treated with western medicine,and the treatment group with acupuncture and Huoxue Quyu prescription.The review Manager 5.4 software was used for the meta-analysis.The evidence level of the outcome indicators was evaluated by the grading of recommendations assessment,development,and evaluation(GRADE)rating system.The TSA 0.9.5.1 Beta software was used to conduct a sequential analysis of the main outcome measures.Results A total of 20 RCTs with 2 127 patients were included.The meta-analysis results showed that:among the main outcome indicators,the recovery rate(RR=1.93,95％CI1.56-2.38,P＜0.000 01)and the total effective rate(RR=1.22,95％CI 1.16-1.29,P＜0.000 01)in the treatment group were higher than those in the control group;there was no statistical difference in adverse reactions between the two groups(RR=0.36,95％CI 0.12-1.12,P=0.08).Among the secondary outcome measures,the score of Visual Analogue Scale(VAS)in the treatment group(MD=-1.55,95％CI-2.39--0.70,P=0.000 3)was lower than that in the control group;there was no statistical difference in the anterior cerebral artery(ACA)blood flow velocity(MD=-1.51,95％CI-3.18-0.16,P=0.08)between the two groups;the middle cerebral artery(MCA)blood flow(MD=-4.12,95％CI-5.76--2.49,P＜0.000 01)and posterior cerebral artery(PCA)blood flow(MD=-2.73,95％CI-4.14--1.32,P＜0.000 1)in the treatment group were lower than those in the control group.The GRADE evidence grading results showed that total effectiveness,recovery rate,adverse reactions,VAS score,and cerebral artery(ACA,MCA,and PCA)blood flow velocities were all low.The sequential analysis of the trials showed that among the main outcome indicators,the included sample size of recovery rate and total effective rate met the requirements of the meta-analysis.However,the adverse reactions still needed to be verified by a larger sample.Conclusion Acupuncture combined with Huoxue Quyu prescription has definite clinical effect on migraine,and can improve cerebral artery blood flow velocity to a certain extent.
万方数据
维普
