Value of serum indicators combined with transvaginal and transabdominal ultrasound in diagnosis of early ectopic pregnancy
Objective To analyze the value of the levels of β-human chorionic gonadotropin(β-HCG),cancer antigen 199(CA199),and progesterone(P)combined with transvaginal and transabdominal ultrasound in the prediction of early ectopic pregnancy.Methods From October 2020 to October 2023,a total of 93 patients suspected with early ectopic pregnancy treated in Yantai Yantaishan Hospital were selected as the study objects;among which,82 patients who were(31.35±3.16)years were confirmed with early ectopic pregnancy by postoperative pathological diagnosis and were set as an observation group.Another 105 women with normal intrauterine pregnancy during the same period were selected as a control group;they were(31.57±3.22)years old.The objects'clinical data were retrospectively collected.The serum levels of β-HCG,CA199,and P,transvaginal and transabdominal ultrasound signs,and diagnostic results of early ectopic pregnancy in the two groups were analyzed and compared by t test and x2 test.The receiver operating characteristic curves(ROC)were drawn.Results The serum levels of β-HCG,CA199,and P in the observation group were lower than those in the control group(all P＜0.05).All the 93 patients took pathological examination,and 82 were positive.The transvaginal ultrasound results showed that 72 cases had early ectopic pregnancy.The transabdominal ultrasound results showed that 69 cases had early ectopic pregnancy.The proportions of the patients with uterine and rectal effusion,original cardiac tube pulsation,adnexal mass,and no pregnancy sac in utero by abdominal ultra sound were lower than those by transvaginal ultrasound(all P＜0.05).The areas under the ROC's of transvaginal ultrasound,transabdominal ultrasound,β-HCG,CA199,P,and their combination were 0.716,0.657,0.630,0.605,0.691,and 0.910;the sensitivities were 65.85％,63.41％,70.73％,58.54％,68.29％,and 86.59％;the specificities were 72.73％,72.73％,63.64％,72.68％,63.64％,and 81.82％.Conclusion Abnormal expressions of levels of serum β-HCG,CA199,and P and transvaginal and transabdominal ultrasound are found in patients with early ectopic pregnancy,and their combined detection has high diagnostic value for patients with early ectopic pregnancy,and may be used as a target for clinical diagnosis and treatment of early ectopic pregnancy.
万方数据
维普
