Relationship of fibrinogen and peripheral blood leukocytes with degree of renal function impairment in patients with diabetic kidney disease
Objective To explore the relationship of fibrinogen(FIB)and peripheral blood leukocytes with the degree of renal function impairment in patients with diabetic kidney disease(DKD).Methods One hundred and sixty-four patients with DKD treated at Shaanxi Hospital of Traditional Chinese Medicine from March 2022 to February 2024 were selected for as the study objects.According to the 24-hour urinary albumin excretion,the patients were divided into a microalbuminuria group[96 patients;30 mg≤24-hour urinary albumin excretion＜300 mg;50 males and 46 females;(55.79±7.27)years old]and a macroalbuminuria group[68 patients;24-hour urinary albumin excretion≥300 mg;36 males and 32 females;(56.50±7.01)years old].The general data,levels of FIB and fibrinogen degradation products(FDP),FIB to albumin ratios(FAR),lymphocyte counts,monocyte counts,neutrophil counts,eosinophil counts,and basophil counts were compared between the two groups.The multifactorial logistic regression was used to analyze the risk factors affecting renal function impairment in the patients with DKD.t andx2tests were applied.Results The levels of blood urea nitrogen(BUN),serum creatinine(Scr),FIB,FDP,and FAR in the macroalbuminuria group were higher than those in the microalbuminuria group[(10.04±3.38)mmol/L vs.(5.83±1.52)mmol/L,(191.59±35.79)mmol/L vs.(81.54±16.10)mmol/L,(3 645.15±725.13)mg/L vs.(2 864.94±759.73)mg/L,(2.05±0.46)mg/L vs.(1.42±0.39)mg/L,and(92.93±33.86)mg/g vs.(73.40±20.40)mg/g],with statistical differences(t=10.772,26.591,6.602,9.455,and 4.598;all P＜0.05).The estimated glomerular filtration rate(eGFR)in the macroalbuminuria group was lower than that in the microalbuminuria group[(42.62±12.40)ml/(min·1.732 m2)vs.(82.43±20.43)ml/(min·1.732 m2)],with a statistical difference(t=14.303;P＜0.05).The monocyte and neutrophil counts in the macroalbuminuria group were higher than those in the microalbuminuria group[(0.48±0.16)×109/L vs.(0.35±0.10)×109/L and(4.21±1.19)x109/L vs.(3.58±0.88)x109/L],with statistical differences(t=6.394 and 3.898;both P＜0.05).There were no statistical differences in the lymphocyte,eosinophil,and basophil counts between the two groups(all P＞0.05).The multifactorial logistic regression analysis revealed that high BUN,Scr,FIB,FDP,FAR,and counts of monocytes and neutrophils,as well as low eGFR were independent risk factors for the severity of renal function impairment in the patients with DKD(all P＜0.05).The Pearson correlation analysis indicated that the levels of FIB,FDP,and FAR and monocyte and neutrophil counts were positively correlated with BUN and Scr,and negatively with eGFR(all P＜0.05).Conclusions In patients with DKD,the levels of FIB,FDP,and FAR and counts of monocytes and neutrophils increase,and are positively correlated with the degree of renal function impairment.These indicators are identified as the independent risk factors affecting the degree of renal function impairment in patients with DKD and can serve as indicators for assessing the progression of DKD.
FibrinogenPeripheral blood leukocytesDiabetic kidney diseaseDegree of renal function impairment
万方数据
维普
