Application of TTPVI based on CT and MRI imaging to display microvascular invasion in patients with liver cancer
Objective To explore the value of two-trait predictor of venous invasion(TTPVI)of CT and MRI in the diagnosis of microvascular invasion in patients with primary liver cancer.Methods One hundred and twelve patients with primary liver cancer admitted to Xi'an Eighth Hospital between June 2022 and September 2023 were selected as the study objects.They were divided into an invasive group and a non-invasive group based on microvascular invasion.The marginal fuzzy signs,TTPVI,and portal vein tumor thrombus(PVTT)of CT or MRI before the operation were compared between the two groups.The diagnostic efficacies of the above indicators for microvascular invasion in the patients with primary liver cancer were analyzed by the receiver operating characteristic curves(ROC).t test,x2 test,and rank sum test were used.Results Among the 112 patients,25 cases(22.32％)experienced microvascular invasion.The proportions of borderline fuzzy signs,TTPVI,and PVTT in the invasive group were 60.00％(15/25),72.00％(18/25),and 16.00％(4/25),respectively,which were significantly higher than those in the non-invasive group(x2=38.968,40.349,and 14.436,all P＜0.05).The incidence rates of edge blurry signs such as multiple sign overlap,multiple nodule fusion,incomplete local capsule,and local protruding nodules in the invasive group were 12.00％(3/25),16.00％(4/25),12.00％(3/25),and 12.00％(3/25),respectively,which were significantly higher than those in the non-invasive group(x2=6.639,10.042,6.639,and 4.285;all P＜0.05).The areas under the ROC's(AUC)of edge blurred signs,TTPVI,and PVTT of CT and MRI for microvascular invasion in the patients were 0.771(95％CI 0.648-0.894),0.828(95％CI 0.723-0.934),and 0.580(9 5％CI 0.443-0.717),respectively.The sensitivity,specificity,positive predictive value,and negative predictive value of preoperative TTPVI in diagnosing microvascular invasion in the patients were 72.00％,89.66％,66.67％,and 91.76％,respectively.The sensitivity,specificity,positive predictive value,and negative predictive value of preoperative blurred signs in diagnosing microvascular invasion in the patients were 60.00％o,94.25％,75.00％,and 89.13％,respectively.The AUC of TTPVI combined with edge blurred signs for microvascular invasion in the patients was 0.821(95％CI 0.703～0.938);the sensitivity,specificity,positive predictive value,and negative predictive value were 76.00％,89.66％,67.86％,and 92.86％,respectively.Conclusion Preoperative blurred edges and TTPVI of CT and MRI have certain diagnostic value for microvascular invasion in patients with primary liver cancer,and their combined efficacy is better.
Primary liver cancerMicrovascular invasionCTMRITwo-trait predictor of venous invasion
万方数据
维普
